Issues in Risk Assessment

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Size: 374 pages, 6 x 9

Publication Year:1993

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Authors:
Committee on Risk Assessment Methodology, National Research Council
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Description:
The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.
The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue ...
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Table of Contents
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Front Matter	i-xviii
Executive Summary	1-12	(skim)
Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity	13-14	(skim)
1 Introduction	15-20	(skim)
2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity	21-42	(skim)
3 Advantages and Disadvantages of Bioassys That Use the MTD	43-52	(skim)
4 Options Considered	53-60	(skim)
5 Conclusions and Recommendations	61-66	(skim)
References	67-78	(skim)
Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment	79-90	(skim)
Appendix B: Workshop Organizing Subcommittee	91-92	(skim)
Appendix C: Workshop Federal Liaison Group	93-94	(skim)
Appendix D: Workshop Programs	95-96	(skim)
Appendix E: Workshop Attendees	97-110	(skim)
Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment	111-172	(skim)
Appendix G: Informal Search for Supercarcinogens	173-184	(skim)
The Two-Stage Model of Carcinogenesis	185-186	(skim)
Issues in Risk Assessment	187-216	(skim)
References	217-222	(skim)
Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis	223-232	(skim)
Appendix B: Workshop Program	233-234	(skim)
Appendix C: Workshop Federal Liaison Group	235-236	(skim)
Appendix D: Workshop Attendees	237-238	(skim)
Appendix E: Workshop Organizing Task Group	239-240	(skim)
A Paradigm for Ecological Risk Assessment	241-242	(skim)
1 Introduction	243-246	(skim)
2 Scope of Ecological Risk Assessment	247-248	(skim)
3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment	249-258	(skim)
4 Key Scientific Problems Limiting Application of Ecological Risk Assessment	259-264	(skim)
5 Conclusions	265-266	(skim)
6 Recommendations	267-268	(skim)
References	269-272	(skim)
Appendix A: Workshop Participants	273-278	(skim)
Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group	279-280	(skim)
Appendix C: Workshop Introduction	281-282	(skim)
Appendix D: Opening Plenary Presentations	283-292	(skim)
Appendix E: Case Studies and Commentaries	293-308	(skim)
Appendix F: Breakout Sessions	309-336	(skim)
Appendix G: Contemplations on Ecological Risk Assessment	337-342	(skim)
Appendix H: Workshop Summary	343-346	(skim)
Appendix I: References for Appendixes	347-350	(skim)
Appendix J: Workshop Program	351-356	(skim)

Description

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.
The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures.
The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

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"Value for money is a frequently heard expression these days and I can truly say that even if I had to pay the cover price of this book, I would have recouped it within a couple of days . . . . I am confident that the students in my risk management course are going to benefit substantially from my ownership of this book during the coming semesters." --Chemistry & Industry,

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