Iodotrifluoromethane:

Toxicity Review

Status: Available Now

Size: 112 pages, 6 x 9

Publication Year:2004

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Authors:
Subcommittee on Iodotrifluoromethane, Committee on Toxicology, National Research Council
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The U.S. military is considering using a compound called iodotrifluoromethane (CF3I) for fire suppression to replace previously-used compounds (halons) that are being phased out because they deplete the ozone layer. This report reviews available toxicological data on CF3I and ...
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Table of Contents
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Front Matter	i-xvi
Summary	1-10	(skim)
1 Introduction	11-14	(skim)
2 Physical and Chemical Properties and Efficacy	15-17	(skim)
3 Health Effects: Toxicity Studies	18-27	(skim)
4 Cardiac Sensitization	28-48	(skim)
5 Physiologically Based Pharmacokinetic Modeling	49-57	(skim)
6 Human Exposure	58-67	(skim)
References	68-73	(skim)
Appendix A: Biographical Information on Subcommittee on Iodotrifluoromethane	74-76	(skim)
Appendix B: Toxicity Review for Iodotrifluoromethane (CF3I): 2002 Update	77-96	(skim)

Description

The U.S. military is considering using a compound called iodotrifluoromethane (CF3I) for fire suppression to replace previously-used compounds (halons) that are being phased out because they deplete the ozone layer. This report reviews available toxicological data on CF3I and evaluates the scientific basis of the U.S. Army's proposed exposure limit of 2,000 parts per million (ppm). The report recommends that CF3I be used for fire suppression in normally unoccupied spaces because of its potential to cause cardiac sensitization in test animals. The report also recommends that further genotoxicity testing be conducted (testing for changes in genetic material), and that CF3I be assessed for its potential to cause cancer. Should the Army decide to use CF3I, information should be collected and evaluated on how much of the chemical or any of its degradation products might be released and how often.

Iodotrifluoromethane:

Toxicity Review

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