Validation of Toxicogenomic Technologies:

A Workshop Summary

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Size: 98 pages, 6 x 9

Publication Year:2007

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Committee on Validation of Toxicogenomic Technologies: A Focus on Chemical Classification Strategies, Committee on Emerging Issues and Data on Environmental Contaminants, National Research Council
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Table of Contents
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Front Matter	i-xiv
Summary of the Workshop	1-38	(skim)
Attachment 1. Experimental Objectives of DNA Microarray Studies	39-48	(skim)
Attachment 2. Comparison of Microarray Data from Multiple Labs and Platforms	49-57	(skim)
Attachment 3. Statistical Analysis of Toxicogenomic Microarray Data	58-65	(skim)
Attachment 4. Diagnostic Classifier Gaining Confidence Through Validation	66-74	(skim)
Appendix A: Workshop Planning Committee Biographical Information	75-78	(skim)
Appendix B: Workshop Agenda	79-81	(skim)
Appendix C: Federal Liaison Group for the NRC Committee on Emerging Issues and Data on Environmental Contaminants	82-84	(skim)

Description

Beginning in the early 1980s, new technologies, began to permit evaluation of the expression of individual genes. Recent technological advances have expanded those evaluations to permit the simultaneous detection of the expression of tens of thousands of genes and to support holistic evaluations of the entire genome. The application of these technologies has enabled researchers to unravel complexities of cell biology and, in conjunction with toxicologic evaluations, the technologies are used to probe and gain insight into questions of toxicologic relevance. As a result, the use of the technologies has become increasingly important for scientists in academia, as well as for the regulatory and drug development process.

Validation of Toxicogenomic Technologies:

A Workshop Summary

Description

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