Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars or trucks transporting EHSs or intentionally through terrorist activities. These substances can also be released by improper storage or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental or intentional releases.
In 1993, the National Advisory Committee was tasked with developing acute exposure guideline levels (AEGLs) for approximately 200 EHSs. This book is the fifteenth interim report from that committee. It summarizes the committee's conclusions and recommendations for improving documents for 16 chemicals and one chemical mixture identified as EHSs. The report also summarizes the committee's conclusions and recommendations for improving a draft white paper that proposes standard operating procedures for using physiologically based pharmacokinetic modeling as a tool in the AEGLs development program.