Advances in biomedical research have increased our understanding of the complex nature of disease and the interaction of multiple molecular pathways involved in cancer. Combining investigational products early in their development is thought to be a promising strategy for identifying effective therapies. The IOM's National Cancer Policy Forum held a workshop to discuss challenges and identify potential solutions to improve collaboration and advance the development of combination investigational cancer therapies.
Table of Contents
|2 Why Combinations and Collaborations Are Necessary||3-10|
|3 Scientific Challenges in Developing Investigational Combination Therapies||11-36|
|4 Overcoming Cultural Challenges to Collaborations||37-42|
|5 Legal Issues in Collaborations||43-52|
|6 Financial Challenges||53-54|
|7 Regulatory Issues||55-62|
|8 Codevelopment of Therapies for HIV as a Model||63-68|
|9 Examples of Collaborations Relevant to Cancer||69-72|
|10 Wrapping Up||73-76|
|Appendix A: Examples of Collaborations||77-90|
|Appendix B: Workshop Agenda||91-96|
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