zero exposure) (E. Budtz-Jørgensen, Copenhagen University, N. Keiding, Copenhagen University, and P. Grandjean, University of Southern Denmark, unpublished material, May 5, 2000). The majority of exposures resulted in hair Hg concentrations that exceeded 5 ppm (24 ppb cord blood). The interquartile range for hair Hg concentration was 3 to 8 ppm (13 to 40 ppb for cord blood) (Grandjean et al. 1992). When models are fitted to the data, they are really capturing the shape of the dose response in this middle range of exposure, as illustrated in Figure 7-5. The figure shows dose-response curves fitted to hair Hg data for the

Front Matter (R1-R20)

Executive Summary (1-12)

Introduction (13-30)

Chemistry, Exposure, Toxicokinetics, and Toxicodynamics (31-71)

Biological Variability (72-104)

Dose Estimation (105-146)

Health Effects of Methylmercury (147-249)

Comparison of Studies for Use in Risk Assessment (250-270)

Dose-Response Assessment (271-303)

Risk Characterization and Public Health Implications (304-332)

Appendix to Chapter 7 (333-336)

Glossary (337-344)