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Monograph of the Council on
Heath Care Technology
Quality of Life and
T~ .
ecnnology
Assessment
.
Frederick Mosteller and
Jennifer Falotic - Taylor, editors
Institute of Medicine
NATIONAL ACADEMY PRESS · WASHINGTON, D.C. · 1989
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THE INSTITUTE OF MEDICINE was chartered in lg70 by the National
Academy of Sciences to enlist distinguished members of appropriate professions
in He examination of policy makers pairing to the health of the public. In this,
the Institute acts under both He Academy's 1863 congressional charter responsi-
bility to be an adviser to the federal government, and its own initiative in
identifying issues of medical care, research, and education.
THE COUNCIL ON HEALTH CARE TECHNOLOGY was established in
1986 by the Institute of Medicine of the National Academy of Sciences as a
public-pr~vate entity to address issues of heals care technology and technology
assessment The council is committed to the well-being of patients as He funda-
menm1 purpose of technology assessment. In pursuing Hat goal, the council
draws on the services of the naiion's experts in medicine, health policy, science,
engineering, and industry.
This monograph was supported in part by a grant to the Council on Health Care
Technology of the ~sutute of Medicine from Be National Center for Health
Services Research and Health Care Technology Assessment of the U.S. Depart-
ment of Health and Human Services (grant no. MS 0552602~. The opinions and
conclusions expressed here are those of the authors and do not necessarily repre-
sent the views of the Department of Health and Human Senices, the Nanona
Academy of Sciences, or any of their constituent parts.
Library of Congress Catalog Card Number 89-62S85
International Standard Book Number ~309-04098-1
Additional copies of this report are available from:
National Academy Press
2101 Constitution Avenue, NW
Washington, DC 20418
S032
Printed in the United States of Hence
First Printing, October 1989
Second Ptinting May 1991
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ACKNOWLEDGMENTS
This monograph was encouraged by me Council on Heals Care Tech-
nology as a con~ibudon of Be Me~ods Pane} in canying out its charge to
develop and Prove the methodologies, techniques, and procedures of
technology assessment. Members of Me Me~ods Parted provided com-
ments concerning the ordeal plan and Me drafts of this volume. ~ He
early stages William N. Hubbard, Richard A. Reuig, and Ennqueta Bond
helped launch the project; Clifford Goodman, Leslie Hardy, and Sharon
Saran have helped it Trough to completion; Kathleen N. Lohr has par-
dcipated in He editing.
The council and He Me~ods Pane] greatly appreciate me willingness
of He authors to produce Heir chapters promptly and Heir help ~ugh-
out He editing of He monograph.
The staff of the Technology Assessment Group of He Harvard School
of Public Heath, especially Mane McPherson, and its Sloan Foundation
project members have aided in br~.n~r~g He project to completion. Peg
Hewitt contributed to the literature searches. The Health Science Policy
Working Group in He Division of Health Policy Research and Education,
supported by me Andrew K. Mellon Foundation, has also helped make
this monograph possible.
· . —
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Council on
Health Care Technology
Chapman
WILLIAM N. HUBBARD, JR.
Former President, The Upjohn
Company
Co-Chainnan
JEREMIAH A. BARONDESS
Irene F. and I. Roy Psaty
D~sunguished Professor of Clinical
Medicine, Cornell University
Medical College
Members
HERBERT L. ABRAMS
Professor of Radiology, Stanford
University School of Medicine
RICHARD E. BEHRMAN
Dean, School of Medicine, Case
Western Reserve University
PAUL A. EBERT
Director, American College of
Surgeons
PAUL S. EN~dACHER
Senior Vice-President and Chief
Medical Director, Metropolitan
Life Insurance Company
MELVIN A. GLASSER
Director, Health Security Action
Council
1V
BENJAMIN L. HOL=S
Vice-President and General
Manager, Medical Products Group,
lIewlett-Packard Company
GERALD D. LAUBACH
President, Pfizer Inc.
WALTER B. MAILER
Director, Employee Benefits,
Chrysler Corporation
WAYNE R. MOON
Executive Vice-President and
Operations Manager, Kaiser
Foundation Health Plan, Inc.
LAWRENCE C. MORRIS, JR.
Senior Vice-President, Health Benefits
Management, Blue Cross and
Bllle Shield Association
FREDERICK MOSTELLER
Roger I. Lee Professor ~mentus),
Harvard School of Public Heals
MARY 0. MUNDINGER
Dean, School of Nursing, Columbia
University
ANNE A. SCITOVSKY
Chief, Health Economics Department,
Palo Alto Medical Foundation
GAIL L. WARDEN
Chief Executive Officer, Group Heals
Cooperative of Pllget Solmd
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Methods Parted
Chairman
FREDERICK MOSTELLER
Roger I. Lee Professor (Emeritus),
Harvard School of Public Health
Co~hairman
HERBERT L. ABRAMS
Professor of Radiology, Stanford
University School of Medicine
Members
RICHARD E. BEHRMAN
Dean, School of Medicine, Case
Western Reserve University
PAUL A. EBERT
Director, American College of
Surgeons
DAVID M. EDDY
Center for Health Policy Research
and Education, Duke University
JOHN H. t-=GUSON
Director, Office of Medical
Applications of Research, National
Institutes of Health
SUSAN D. HORN
Associate Director, Center for
Hospital Finance and Management,
Johns Hopkins University School of
Hygiene and Public Health
BRYAN R. LUCK
Senior Research Scientist, Battelle
Human Affairs Research Centers
ANNE A. SCITOVSKY
Chief, Health Economics Deparunent,
Palo Alto Medical Foundation
STEPHEN B. THACKER
Assistant Director for Sciences,
Center for Environmental Health,
Atlanta, Georgia
ELEANOR TRAVERS
Chair, Task Force on Technology
Assessment, Veterans Administration
NORMAN W. WEISSMAN
Director, Division of Extramural
Research, National Center for
Health Services Research
v
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PREFACE
An the recent past me interests of different groups concern with
heal care have focused on He use of medical technologies their ~m-
pacts on safety, efficacy, and electiveness; cost-effectiveness and cost-
benefit; quality; and Heir social, legal, and ethical implications. The sum
of these varied interests is He field of heady care technology assessment.
The Council on Heady Care Technology was created to promote He
development and application of technology assessment In heath care and
me review of heath care technologies for Heir appropriate use. The
council was established as a public-pnvate enterprise at He Institute of
Medicine, a component of the Nabonal Academy of Sciences, Trough the
Heath Promotion and Disease Prevention Amendments of 1984 O>~. 98-
55l, later~ended by.. 99-117~. ~ 1987 He U.S. Congress extended
support for He council as a public-pnvate venture for an additional three
years (by Pa. 100-1771.
The goals and objectives of He council, as stated In He report of its first
two years of operation, are "to promote the development and application
of technology assessment In medicine and to review medical technologies
for their appropriate use. The council is guided in its efforts by the belief
that the fundamental purpose of technology assessment is to improve
well-being and He quality of care." In pursuing these goals He council
seeks to improve the use of medical technology by developing and evalu-
ating the measurement criteria and He mesons used for assessment; to
promote education and training In assessment methods; and to provide
technical assistance in the use of data from published assessments.
The council conducts its activities Trough several working and liaison
panels. Members of these panels reflect a broad set of interested constitu-
encie~physicians and other health professionals, patients and Heir fami-
lies, payers for care, biomedical and heady services researchers, manufac-
turers of heal~-related products, managers and administrators throughout
the heady care system, and public policymakers. In addition, it carries out
councilwide activities that utilize the specific assignments of more Han
one panel.
This monograph contributes to the series of occasional publications of
the council in carrying out its several missions. A guiding principle of He
council is a special focus on outcome measures Hat coincide win patient
well-being, quality of heals care, and quality of life.
William N. Hubbard, Ir., Chairman
Jeremiah A. Barondess, Co-Chainnan
· .
V11
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CONTENTS
1. Conceptual Background and Issues in Quadity of Life .....
Rathieen N. Lohr
2. The Use of Quality-of-Life Measures in Technology
Assessment . ~ e ~ e e e ~ - e ~ ~ ~ e e e e ~ e e e e e e · - e e e e · ~ e · -
Jennifer Falotico-T~ylor, Mark McClellan, arm
Frederick Mosteller
Twelve Applications of Quality-of-Life Measures to
Technology Assessment, 14
3. Quality-of-Life Measures In Liver Transplantation
Mark S. Roberts
4. Quadity-of-Life Measures and Me~ods Use to Study
Andhypertensive Medications ............................
So! Levine and Sydney H. Croog
The Use of Quality-of-Life Measures in Me Private Sector .
Bryan R. Luce, Joan M. WeschEer, aru] Carol Underwood
Assessing Quality of Life: Measures and Utility ....
]. Ivan Williams and Sharon Wood-Dauphinee
Wee Sources of Descnptive Information for
Quality-of-Life Measures. 83
Ten Review Forms for Quality-of-Life Measures, 89
7.
Applications of Quality-of-Life Measures and Areas for
Cooperative Research . e ~ e e e e e e e e e e e e e e
Jennifer FaEotico-TayEor and Fredlerick MosteEEer
The Authors
7
e 45
51
e 55
6s
e
6
9
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