the Aging Mind

Opportunities in Cognitive Research

Committee on Future Directions for Cognitive Research on Aging

Paul C. Stern and Laura L. Carstensen, editors

Board on Behavioral, Cognitive, and Sensory Sciences

Commission on Behavioral and Social Sciences and Education

National Research Council

NATIONAL ACADEMY PRESS
Washington, D.C.



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The Aging Mind: Opportunities in Cognitive Research the Aging Mind Opportunities in Cognitive Research Committee on Future Directions for Cognitive Research on Aging Paul C. Stern and Laura L. Carstensen, editors Board on Behavioral, Cognitive, and Sensory Sciences Commission on Behavioral and Social Sciences and Education National Research Council NATIONAL ACADEMY PRESS Washington, D.C.

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The Aging Mind: Opportunities in Cognitive Research NATIONAL ACADEMY PRESS 2101 Constitution Avenue, N.W. Washington, D.C. 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This work was supported by Task Order 55 under NIH Contract No. N01-OD-4-2139 between the National Academy of Sciences and the National Institutes of Health, U.S. Department of Health and Human Services. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project. Suggested citation: National Research Council (2000) The Aging Mind: Opportunities in Cognitive Research. Committee on Future Directions for Cognitive Research on Aging. Paul C. Stern and Laura L. Carstensen, editors. Commission on Behavioral and Social Sciences and Education. Washington, DC: National Academy Press. Library of Congress Cataloging-in-Publication Data The aging mind: opportunities in cognitive research / Committee on Future Directions for Cognitive Research on Aging ; Paul C. Stern and Laura L. Carstensen, editors. p. cm. Includes bibliographical references and index. ISBN 0-309-06940-8 (pbk.) 1. Cognition—Age factors. 2. Ability, Influence of age on. I. Stern, Paul C. II. Carstensen, Laura L. III. National Research Council. Committee on Future Directions for Cognitive Research on Aging. IV. Title. BF724.55. C63 A48 2000 155.67′13—dc21 00-008630 Additional copies of this report are available from National Academy Press, 2101 Constitution Avenue, N.W., Washington, D.C. 20418 Call (800) 624-6242 or (202) 334-3313 (in the Washington metropolitan area) This report is also available online at http://www.nap.edu Copyright 2000 by the National Academy of Sciences. All rights reserved. Printed in the United States of America

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The Aging Mind: Opportunities in Cognitive Research THE NATIONAL ACADEMIES National Academy of Sciences National Academy of Engineering Institute of Medicine National Research Council The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M. Alberts is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. William A. Wulf is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M. Alberts and Dr. William A. Wulf are chairman and vice chairman, respectively, of the National Research Council.

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The Aging Mind: Opportunities in Cognitive Research COMMITTEE ON FUTURE DIRECTIONS FOR COGNITIVE RESEARCH ON AGING Laura L. Carstensen (Chair), Department of Psychology, Stanford University Paul B. Baltes, Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin Deborah M. Burke, Department of Psychology, Pomona College Caleb E. Finch, Division of Neurogerontology, University of Southern California Reid Hastie, Center for Research on Judgment and Policy, Department of Psychology, University of Colorado Richard J. Jagacinski, Department of Psychology, Ohio State University Hazel R. Markus, Department of Psychology, Stanford University Timothy A. Salthouse, School of Psychology, Georgia Institute of Technology Larry R. Squire, Veterans Affairs Medical Center, San Diego and Departments of Psychiatry, Neuroscience, and Psychology, University of California, San Diego Rudolph E. Tanzi, Department of Neurology, Massachusetts General Hospital, and Department of Neurology, Harvard University Keith E. Whitfield, Department of Biobehavioral Health, Pennsylvania State University William A. Yost, Parmly Hearing Institute, Loyola University Chicago Paul C. Stern, Study Director Cecilia Rossiter, Project Assistant

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The Aging Mind: Opportunities in Cognitive Research BOARD ON BEHAVIORAL, COGNITIVE, AND SENSORY SCIENCES Anne Petersen (Chair), W.K. Kellogg Foundation, Battle Creek, MI Linda M. Burton, Center for Human Development and Family Research, Pennsylvania State University Stephen J. Ceci, Department of Human Development, Cornell University Eugene K. Emory, Department of Psychology, Emory University Rochel Gelman, Department of Psychology, University of California, Los Angeles Anthony Jackson, Disney Learning Initiative, Burbank, California Peter Lennie, Department of Science, New York University Marcia C. Linn, Graduate School of Education, University of California, Berkeley Elissa Newport, Department of Brain and Cognitive Sciences, University of Rochester Charles R. Plott, Division of Humanities and Social Sciences, California Institute of Technology Michael Rutter, Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London Arnold Sameroff, Center for Human Growth and Development, University of Michigan Edward E. Smith, Department of Psychology, University of Michigan Larry R. Squire, Veterans Affairs Medical Center, San Diego and Departments of Psychiatry, Neuroscience, and Psychology, University of California, San Diego Robert J. Sternberg, Department of Psychology, Yale University James W. Stigler, Department of Psychology, University of California, Los Angeles John A. Swets, BBN Corporation, Belmont, Massachusetts Esther Thelen, Department of Psychology, Indiana University Richard F. Thompson, Neuroscience Program, University of Southern California William A. Yost, Parmly Hearing Institute, Loyola University Chicago Christine R. Hartel, Director

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The Aging Mind: Opportunities in Cognitive Research Contents     Preface   ix     Executive Summary   1 1   Understanding the Aging Mind   7     A Conceptual Framework   9     Identifying Research Opportunities   11     About This Book   12 2   Neural Health   14     Recent Scientific Developments   15     Research Initiative on Neural Health   17     Implementation Issues   19 3   Cognition in Context   21     Recent Scientific Developments   22     Research Initiative on Cognition in Context   30 4   Structure of the Aging Mind   37     Recent Scientific Advances   38     Research Initiative on the Structure of the Aging Mind   50

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The Aging Mind: Opportunities in Cognitive Research 5   Implementation   54     Organization of Research Support   54     Promoting Interdisciplinary Research   55     Research Infrastructure   56     Collaboration Across Institutes   62     References   64     Appendixes         A Age-Related Shifts in Neural Circuit Characteristics and Their Impact on Age-Related Cognitive Impairments John H. Morrison   83     B Homeostatic Processes in Brain Aging: The Role of Apoptosis, Inflammation, and Oxidative Stress in Regulating Healthy Neural Circuitry in the Aging Brain Carl W. Cotman   114     C The Bearable Lightness of Aging: Judgment and Decision Processes in Older Adults Ellen Peters, Melissa L. Finucane, Donald G. MacGregor, and Paul Slovic   144     D Cognitive Aging and Adaptive Technologies Donald L. Fisher   166     E Health Effects on Cognitive Aging Shari R. Waldstein   189     F Cultural Variations in Cognition: Implications for Aging Research Shinobu Kitayama   218     G Functional Magnetic Resonance Imaging of the Brain in Nonhuman Primates: A Prospectus for Research on Aging Thomas D. Albright   238     H Biographical Sketches   251     Index   259

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The Aging Mind: Opportunities in Cognitive Research Preface Over the past decade, the fields of cognitive science and neuroscience have made major contributions to the study of human cognition. In doing so, these fields have become increasingly interdependent. Arguably, nowhere have these gains been more relevant and substantial than in the areas of cognitive and neuroscience research on aging. Understanding how and why cognitive functioning changes with age offers great promise for improving the lives of older citizens in the United States, who are a growing segment of the population. Recognizing the urgency and the importance of these lines of research to a rapidly aging society, the National Institute on Aging (NIA) called for a "reappraisal of research opportunities that will further our understanding of how cognition develops and changes with age" (statement of Ronald Abeles, NIA, to the National Research Council Board on Behavioral, Cognitive, and Sensory Sciences, August 11, 1998). In early 1999, the NIA asked the National Research Council (NRC) to evaluate the field of cognitive aging in order to identify areas of opportunity in which additional research would substantially improve basic understanding of cognitive functioning in aging, by drawing on recent developments in behavioral science, cognitive science, and neuroscience that are not yet fully applied to this subject area. The NRC, through the Board on Behavioral, Cognitive, and Sensory Sciences, created the Committee on Future Directions for Cognitive Research on Aging to undertake this task. The committee, which I had the honor of chairing, was asked to identify a small number of significant and promising research opportunities in cognition and aging in neuroscience, cognitive science, and behavioral science, in some cases empha-

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The Aging Mind: Opportunities in Cognitive Research sizing research opportunities that would have the added benefit of linking these three approaches in new ways. The committee was asked to work very quickly. It held three meetings in June, August, and November 1999, at which it identified a variety of possible research opportunities and considered the promise of each. Without exception, every member of the committee worked diligently toward the requested end. Through informal processes of consultation and deliberation, the committee arrived at its consensus recommendations to the NIA. As the committee considered priorities, it invited the input of a number of outside specialists representing critical areas to make possible a deeper discussion of the more promising areas of opportunity. Some of the guests of the committee discussed these areas at the August meeting and at a committee-sponsored workshop in November 1999. Committee members were, to a person, dedicated scientists concerned about the future of their fields and even more so about the future of the rapidly maturing population. Richard J. Hodes, director of the NIA, deserves substantial praise for requesting this report. The committee thanks Ronald Abeles, now special assistant to the director of the Office of Behavioral and Social Sciences Research at the National Institutes of Health, for his stewardship as the NIA project officer in support of the study. The committee is also grateful for their efforts and support to Marcelle Morrison-Bogorad, NIA associate director for neuroscience and neuropsychology of aging, and Richard Suzman, NIA associate director for behavioral and social research as well as to Jared Jobe, Andrew Monjan, and Molly Wagster, program officers for the NIA's cognitive research programs. The committee also received exceptionally wise counsel from Barbara Torrey, executive director of the National Research Council's Commission on Behavioral and Social Sciences and Education, for which we are deeply grateful. Cecilia Rossiter, the project assistant for the committee, was not only efficient and considerate but went far above and beyond the call of duty by offering insights into the report as well. The committee also owes thanks to Christine McShane, who provided thorough, constructive, and efficient editing for the entire volume, and to Carrie Muntean, who readied the manuscript for publication. However, there is one person and one person alone who made this report possible in the very short time frame allocated. That person is study director Paul Stern. His ability to listen astutely, to integrate committee generated ideas effectively, and to write skillfully and efficiently, allowed us to proceed within the time constraints of our task. Although I owe my deepest thanks to all of the committee members who took up this work, the report you read herein would not exist without Paul Stern. We also owe special thanks to several experts from outside the committee whose input was valuable. Prominent among these individuals are the au-

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The Aging Mind: Opportunities in Cognitive Research thors of the seven background papers for the committee, which appear in Appendixes A-G: John Morrison of Mount Sinai School of Medicine; Carl Cotman of the University of California, Irvine; Ellen Peters, Melissa L. Finucane, Donald MacGregor, and Paul Slovic of Decision Research; Donald Fisher of the University of Massachusetts; Shari Waldstein of the University of Maryland, Baltimore County; Shinobu Kitayama of Kyoto University; and Thomas Albright of the Salk Institute. In addition, we benefited considerably from the comments and presentations by John Breitner of Johns Hopkins University, John Desmond of Stanford University, Roger A. Dixon of the University of Victoria, Ronald McKay of the National Institute of Neurological Disorders and Stroke, John Nesselroade of the University of Virginia, Christian Pike of the University of Southern California, Susan Resnick of the National Institute on Aging, and Esther Thelen of Indiana University, all of whom influenced the committee in important ways. This report and the background papers in the appendixes have been reviewed by individuals chosen for their diverse perspectives and technical expertise in accordance with procedures approved by the National Research Council's Report Review Committee. The purpose of this independent review was to provide candid and critical comments that would assist the institution in making the published report as accurate and as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscripts remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their participation in the review of this report: Marilyn S. Albert, Departments of Psychiatry and Neurology, Massachusetts General Hospital and Harvard Medical School; Fredda Blanchard-Fields, School of Psychology, Georgia Institute of Technology; Fergus Craik, Department of Psychology, University of Toronto; William Estes, Department of Psychology, University of Indiana; Donald L. Fisher, Department of Mechanical and Industrial Engineering, University of Massachusetts; John Gabrieli, Department of Psychology, Stanford University; Arthur Kramer, Beckman Institute, University of Illinois; Leah L. Light, Department of Psychology, Pitzer College; Richard Shiffrin, Department of Psychology, Indiana University; and Arthur Wingfield, Department of Psychology and Volen National Center for Complex Systems, Brandeis University. We also wish to thank the following individuals for their participation in the review of the seven papers included as appendices in this volume: Merrill F. Elias, Department of Psychology, University of Maine; John Gabrieli, Department of Psychology, Stanford University; Andrea LeBlanc, Department of Neurology and Neurosurgery, McGill University; George Loewenstein, Department of Social and Decision Sciences, Carnegie Mellon University; Denise Park, Institute for Social Research, Research Center for Group

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The Aging Mind: Opportunities in Cognitive Research Dynamics, University of Michigan, Ann Arbor; William Rouse, Enterprise Support Systems; and Wendy Suzuki, Center for Neural Science, New York University. Although the individuals listed above provided constructive comments and suggestions, it must be emphasized that responsibility for the final content of this report rests entirely with the authoring committee and the institution; responsibility for the papers in the appendices rests entirely with their authors. The committee has identified some key research directions that will, if vigorously pursued, lead to sharply increased understanding of cognitive change in older adults and new opportunities to improve their functioning and quality of life. Laura L. Carstensen, Chair Committee on Future Directions for Cognitive Research on Aging

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The Aging Mind: Opportunities in Cognitive Research the Aging Mind

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