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Toxicological Effects of Methylmercury (2000)
Commission on Life Sciences (CLS)

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284
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Toxicological Effects of Methylmercury

TABLE 7-2 Benchmark Dose Calculations (ppm MeHg in maternal hair) from Various Studies and for Various End Points

Study

End Point

BMDa

BMDL

Seychellesb

Bender Copying Errors

***e

25

 

Child Behavior Checklist

21

17

 

McCarthy General Cognitive

***

23

 

Preschool Language Scale

***

23

 

WJ Applied Problems

***

22

 

WJ Letter/Word Recognition

***

22

Faroe Islandsc

Finger Tapping

20

12

 

CPT Reaction Time

17

10

 

Bender Copying Errors

28

15

 

Boston Naming Test

15

10

 

CVLT: Delayed Recall

27

14

New Zealandd

TOLD Language Development

12

6

 

WISC-R:PIQ

12

6

 

WISC-R:FSIQ

13

6

 

McCarthy Perceptual Performance

8

4

 

McCarthy Motor Test

13

6

aBMDs are calculated from the K-power model under the assumption that 5% of the responses will be abnormal in unexposed subjects (P0 = 0.05), assuming a 5% excess risk (BMR = 0.05).

bData from Crump et al. 1998, 2000. “Extended” covariates.

cData from Budtz-Jørgensen et al. 1999.

dData from Crump et al. 1998, 2000.

e *** indicates value exceeds 100.

Abbreviations: WJ, Woodcock-Johnson Tests of Achievement; CPT, Continuous Performance Test; CVLT, California Verbal Learning Test; TOLD, Test of Language Development; WISC-R:PIQ, Wechsler Intelligence Scale for Children-Revised Performance IQ; WISC-R:FSIQ, Wechsler Intelligence Scale for Children-Revised Full-Scale IQ.

RfD). In a traditional setting, NOAELs are computed for each end point in each study, and the point of departure would most likely be chosen to correspond to the highest observed NOAEL. In the present setting, however, where BMDs and BMDLs are calculated instead of NOAELs, the appropriate choice is not immediately clear. It is not necessarily

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