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Nobel Prize Women in Science: Their Lives, Struggles, and Momentous Discoveries, Second Edition (1993)
Joseph Henry Press (JHP)

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National Research Council. "Front Matter." Nobel Prize Women in Science: Their Lives, Struggles, and Momentous Discoveries, Second Edition. Washington, DC: The National Academies Press, 1993. 1. Print.

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Nobel Prize Women · ~ ~ m Science Their Lives, Struggles, and Momento?ls Discoveries SECOND EDITION Sharon Bertsch McGrayne JOSEPH HENRY PRESS Washington, D.C.

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Bare-breasted woman adorns the reverse of the Nobel Prize medals for physics and chernistry. Copyright Nobel Foundation

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Nobel Prize Women in Science Their Lives, Struggles, and Momentous Discoveries SECOND EDITION Sharon Bertsch McGrayne JOSEPH HENRY PRESS Washington, D.C.

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Joseph Henry Press · 2101 Consdmdon Avenue, N.W. · Washington, D.C. 20418 TheJoseph Hemy Press, am imprint of the National Academy Press, was created with the goal of making books on science, technology, amd health more widely avail- able to professionals and the public.Joseph Hemy was one of the founders of the National Academy of Sciences and a leader of early American science. Any opinions, findings. condusions, or recommendations expressed m dais volume are those of the author and do not necessarily reflect the views of the National Acad- emy of Sciences or its affiliated institutions. Library of Congress Cataloging-in-Publicadon Data McGrayne, Sharon Bertsch. Nobel Prize women m science: their lives, struggles, and momentous discoveries Sharon Bertsch McGrayne.—Updated cd. p.cm. ISBN 0-309-07270-0 pbk.) 1. Women scientists—Awards. 2. Science—Awards. 3. Nobel Prizes. 1. Tide. 141.M358 1998 509 2'2—dc21 Designed by Ardashes Hampariam Copyright 1993, 1998 Sharon Bertsch McGrayne Printed in the United States of America 98-39490 CIP

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TO Hilde Proescholdt Mangold 1898-1924 llilde Proescholdt Mangold's doctoral thesis in biology won her ad- viser a Nobel Prize. Mangold conducted the crucial experiments demonstrating the nature and location of the organizer, the chemi- cals that direct the embryonic development of different tissues and organs. Unlike the other women in this book, Hilde Proescholdt Mangold did not conceive of or design her experiment. Her adviser, Hans Spemar~n, did so. She executed the project umder his direction. In 1924, the gas heater in Mamgold's kitchen exploded. Hilde Proescholdt Mangold, the twenty-six-year-old mother of an infant son and the codiscoverer of the organizer, died of severe burns. Eleven years after her death, Spemann won the Nobel Prize. Frieda Rob.~clzeit-RobbzrLs 1893-December 18, 1973 For thirty-eight years Frieda Robscheit-Robbins was the research partner of George Hoyt Whipple. Although their joint work led to a cure for the deadly disease pernicious anemia. it was Whipple alone who won a Nobel Prize for Physiology or Medicine in 1934. KWhipple's experiments," the Nobel Committee observed, "were planned exceedingly well and carried out very accurately, amd consequently their results can lay claim to absolute reliability." Frieda Robscheit-Robbins helped to plam and carried out those experiments. In fact, she was listed as the first author on Whipple's most im- portant single paper, the report on which his scientific reputation rested. Generally, the first author is primarily responsible for the work summarized in the paper. Whipple cited twenty-three scientific papers in his Nobel ad- dress. Of these, Robschiet-Robbins was the coauthor of ten. Whipple shared his prize money with Robscheit-Robbins and with two women technicians. Frieda Robscheit-Robbins was both in Germany, educated in Chicago amd California, and received her Ph.D. from the University of Rochester. She worked with Whipple from 1917 until her retire- ment from the University of Rochester Medical School in 1955. Af-

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vi DEDICATION ter thirty-eight years, she was still am associate in pathology, a junior- grade employee. Of scientific research she said, "You become possessed of a mag- nificent obsession and determination to learn the truth of your scien- tific theory if it takes sixteen years or many times sixteen. If you are successful, you really deserve no great credit, for by that time experi- ment has become the only thing in life you care to do."

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Contents Acknowledgments Author to Reader L · A Passion for Discovery FIRST GENERATION PIONEERS 2 · Marie Sklodowska Curie 3 · Lise Meitner 4 · Emmy Noetber SECOND GENERATION · Gerty Radnitz Cori ~ · Irene Joliot- Curie 7 · Barbara McClintock 3 · Maria Goeppert Mayer ~ · Rita Levi-Montalcini 10 · Dorothy Crowfoot Hodgkin 11 · Chien-Shiung Wu 12 · Gertrude Belle Elion 13 · Rosalind Elsie Franklin 14 · Rosalyn Sussman Yalow THE NEW GENERATION 15 · Jocelyn Bell Burnell 16 · Christiane Nusslein-Volhard Afterword Notes vu ix xi 3 11 37 64 93 117 144 175 201 225 254 279 303 332 357 378 406 408

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viu CONTENTS Picture Acknowledgments Index About the Author viu 430 433 460

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Acknowledgments SINCE THE EIRST EDITION OE THIS BOOK APPEARED a tenth woman scientist has won a Nobel Prize. Christiane Nusslein-Volhard won the Nobel Prize in Medicine or Physiology in 1995 for helping explain how embryos develop in flies, fish, people, and a host of other creatures. Her Nobel made a new and expanded edition of J~ol6el Prize Womerr ~ Science necessary The lives of the fifteen women in this book illustrate the chang- ing patterns of discrimination against women in science, starting with legal bars to academic high schools and universities in Europe, and continuing in the United States with laws against working wives in universities. The new chapter on Christiame Nusslein-Volhard brings the book full circle. Many of the problems that women have faced m North America and Europe have been exacerbated by Germam atti- tudes about research science and working wives. Thus, Christiame Nusslein-Volhard's experiences cast light on the lives of women far beyond the borders of her native Germamy. At the same time, she herself raises a difficult issue. With the decline in overt discrimination against women in science, we may be approaching an era of more equal opportunity. If that is the case, the future of women in science depends on what women wamt to make of it. Their future will be up to them, and not to others. For this book Drs. Jocelyn Bell Burnell, Dorothy Crow foot Hodgkin, Barbara McClintock, Rita Levi-Montalcini, Christiane Nusslein-Volhard, C. S. Wu, Rosalyn S. Yalow, and Gertrude B. Elion graciously granted personal interviews. Each chapter—whether its subject is alive or deceased—is also based on primary and secondary sources and on extensive inter- views with colleagues, students, family, friends, and experts in each field. Their cooperation is testimony to the importance that leaders of the scientific community place on attracting more woman to sci- ence. ix

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x ACKNOWLEDGMENTS All scientific explanations are nontechnical. Nothing is made up or fictionalized, however. All quotations come from published sources or from interviews. In many cases, the research revealed new material about these women, their lives, amd their accomplishments. Sources and recommended reading are provided at the end of the book I want to thank George E Bertsch for many invaluable discus- sions on editorial and scientific questions. I would also like to ac- knowledge the helpful comments made by Ruth Ann Bertsch amd Frederick M. Bertsch. The staff of the Michigan State University li- braries, especially the reference department of the main library and Diane Clark of the physics library, were extremely helpful as well. Particular thanks go to my agents, Julian Bach retired, and Susan Rabiner, and to copy editor Connie M. Parkinson and to production supervisor Donald J. Davidson at Carol Publishing Group. The following persons deserve special thanks because they care- fully read and advised me on one or more of the chapters in manu- script: Bruce Alberts, Ruth Hogue Angeletti Frederick M. Bertsch, George E Bertsch Ruth Ann Bertsch Jacob Bigeleisen Gloria Blatt, Verena Brink, Peter A. Brix,James Burchall, Alice Calaprioe, Donald L. D. Caspar, Mildren Cohen, Stanley Cohen, Mildred S. Dresselhaus, Elizabeth E. K. Edwards, Jenny P. Glusker, James Goodman, Viktor Hamburger, Anne Harrison, William Havens, Gunter Herrmann, Linda Cooke Johnson, Charles Kimberling, David M. Kipnis, Aaron Klug, Thomas A. Krenitsky, Helene Langevin-Joliot, Joseph Larner, Leon J. Lidofsky, Neil Madsen Jo- seph Meites, Ben Mottelson, Emiliama Pasca Noether, Hans Noll, Markus Noll, Ronald Oppenheim, Jeremiah P. Ostriker, Richard E. Phillips, Robert Provine, Robert G. Sachs, Anne Sayres, David Sayres, Paul Schedl, Hartmut Schultz, Trudi Schupbach, Barbara Sears, Ruth L. Sime, Susam Simkin, Martha K. Smith,Joseph Taylor, Kenneth Trueblood, Alexander Tulinsky, Marcia Vam Ness, Robert Ward, Spencer R. Weart, Alycia Weinberger, Eric Wieschaus, and Evelyn Within.

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Author to Reader ALFRED NOEEE, the Swedish inventor of dynamite, died in 1896, establishing with his fortune the most famous of all interna- tional awards, the Nobel Prizes. Following the dictates of his will, annual awards are given for peace and literature and for discoveries in physics, chemistry, and physiology or medicine. An economics prize was added in 1968. When the awards were established, a single prize represented a fortume: thirty times the annual salary of a university professor, two hundred times that of a skilled construction worker. Awards were made for a discovery or improvement that had been made the pre- ceding year and that had conferred the greatest benefit on mankind. Prominent scientists throughout the world nominate candidates for the science awards. The physics and chemistry winners are cho- sen by the Swedish Academy of Sciences, amd physiology or medi- cine winners are named by the Karolinska Institute in Stockholm. Nobel laureates are the aristocrats of science, the elite, the cream of the crop. Approximately five hundred men have received science Nobels since 1901. In the course of almost a century, only ten women scientists have won Nobel prizes, a mere two percent. This book examines the lives and achievements of fifteen women scientists who either won a Nobel Prize or played a crucial role in a Nobel Plize-winriing project. It offers one answer to the question: Why so few women? xi

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