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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. 
Fig. 7. Nucleotide alignment of two Msp-2 gene sequences to manifest the repeats within RHR3 of P. falciparum OKS. This repeat region is not present in P. falciparum 3D7 or P. reichenowi. The repeat region of OKS continues contiguously from first to second to third to fourth row, left to right. locally. We have noted that nucleotide diversification can result from either intrahelical or interhelical events. An example of intrahelical recombination is that of mitotic, slipped-strand mismatch repair, which is considered to be the principal source of variation in repetitive units such as satellite DNA (Fig. 5). Interhelical recombination derives from the classical process of meiotic crossing over and recombination within or between loci on homologous chromosomes. Both of these processes occur in P. falciparum. Kerr et al. (40) have shown that meiotic, interhelical recombination occurs between mixed Msp-2 genotype parasites passaged in laboratory animals. This process constitutes the basis for generating linkage maps of P. falciparum chromosomes (28). But we have shown that, despite the abundant intragenic recombination within Csp CR, there is an apparent absence of recombination between the 5′ and 3′ NR regions, suggesting that the duplication and deletion of RATs occur by mitotic processes such as the slipped-strand process modeled in Fig. 5 (16). This process also has been implicated as the cause of repeat variation in Msp-2 (38). The debate over the relevance of sexual recombination between P. falciparum types may remain unsettled for some time. It is becoming increasingly clear that the population structure of P. falciparum may not be uniform throughout the species, but depends on local factors related to parasite, vector, and host biology (5,41 –43). An accurate determination of these factors is contingent on careful analysis of parasite genotypes and appropriate determination of homologous comparisons. 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