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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001)
Food and Nutrition Board (FNB)
Institute of Medicine (IOM)

Citation Manager

. "9 Iron." Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press, 2001.

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

menstrual loss of 0.45 mg/day of iron. Therefore, the requirement is increased by approximately 2.5 mg/day of iron.

Adults Ages 19 Years and Older

Method Used to Estimate the Average Requirement

Factorial modeling was used to calculate the EAR and RDA for adult men and women (see “Selection of Indicators for Estimating the Requirement for IronFactorial Modeling”). Requirements for maintaining iron requirements were derived by estimating losses. No provision is made for growth beyond age 19 years, and therefore there is no allowance for deposition of tissue iron.

Men. Basal iron loss was the only component used to estimate total needs for absorbed iron. Basal losses are based on the study by Green and coworkers (1968). Basal iron losses are taken as related to body weight (14 μg/kg/day), and for adult men, the requirement for absorbed iron is equivalent to the basal losses:

Basal losses (mg/day) = Weight (kg) × 0.014 mg/kg/day. (1)

There are insufficient data for estimating variability of basal losses in adult men. Therefore, the median and variability for basal losses were calculated by using the median and variability values for body weight reported in NHANES III. Because variability in body weight is needed for calculating the distribution of basal losses, the reference weights in Table 1-1 were not used. Recorded weights reasonably yield a normal distribution based on the square root of the median weight for men:

Weight 77.4 (kg)0.5 = 8.8 ± 0.84 kg. (2)

The distribution of basal losses, and therefore requirements in men, was obtained by combining equations (1) and (2). The estimated median daily iron loss in men living in the United States—and therefore the median requirement for absorbed iron—is 1.08 mg/day (77.4 kg × 0.014 mg/kg/day). The ninety-seven and one-half percentile of absorbed iron requirements is 1.53 mg/day.

The upper limit of dietary iron absorption was estimated to be 18 percent (see “Factors Affecting the Iron Requirement—Algorithms for Estimating Dietary Iron Bioavailability”). Using this value, the EAR is 6 mg/day (1.08 mg/day ÷ 0.18).

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Front Matter (R1-R24)
Summary (1-28)
1 Introduction to Dietary Reference Intakes (29-43)
2 Overview and Methods (44-59)
3 A Model for the Development of Tolerable Upper Intake Levels (60-81)
4 Vitamin A (82-161)
5 Vitamin K (162-196)
6 Chromium (197-223)
7 Copper (224-257)
8 Iodine (258-289)
9 Iron (290-393)
10 Manganese (394-419)
11 Molybdenum (420-441)
12 Zinc (442-501)
13 Arsenic, Boron, Nickel, Silicon, and Vanadium (502-553)
14 Uses of Dietary Reference Intakes (554-579)
15 A Research Agenda (580-586)
Appendix A Origin and Framework of the Development of Dietary Reference Intake (587-590)
Appendix B Acknowledgments (591-593)
Appendix C Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (594-643)
Appendix D Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (644-653)
Appendix E Dietary Intake Data from the U.S. Food and Drug Administration Total Diet Study, 1991-1997 (654-673)
Appendix F Canadian Dietary Intake Data, 1990 (674-679)
Appendix G Biochemical Indicators for Iron, Vitamin A, and Iodine from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (680-691)
Appendix H Comparison of Vitamin A and Iron Intake and Biochemical Indicators from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (692-696)
Appendix I Iron Intakes and Estimated Percentile of the Distribution of Iron Requirements from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (697-703)
Appendix J Glossary and Acronyms (704-708)
Appendix K Conversion of Units (709-709)
Appendix L Options for Dealing with Uncertainties (710-714)
Appendix M Biographical Sketches of Panel and Subcommittee Members (715-728)
Index (729-769)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Vitamins (770-771)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Elements (772-773)