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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
TABLE 12-7 Effect of Increasing Doses of Zinc (Zn) Intake on Copper (Cu) Status
a The authors note it was not possible to separate the effects of sickle cell disease and copper depletion.
b Copper status was assessed by the activities of the copper-metalloenzymes, plasma ferroxidase (ceruloplasmin), and erythrocyte Cu,Zn-superoxide dismutase. No significant differences in the plasma copper levels or the ferroxidase activities between the supplemented and control groups could be detected at 2, 4, or 6 weeks. ESOD = erythrocyte copper-zinc superoxide dismutase.
of copper status (such as ceruloplasmin or serum copper concentration) were considered optimal for the dose-response assessment.
Identification of a No-Observed-Adverse-Effect Level (NOAEL) and Lowest-Observed-Adverse-Effect Level (LOAEL). A LOAEL of 60 mg/day is based on the study of Yadrick and coworkers (1989) who evaluated copper status after supplemental intake of 50 mg/day as zinc glu-
