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Duration

Cu Intake (mg/d)

Adverse Effects

2 y

Not provided

Cu deficiency anemiaa

Decreased serum Cu and ceruloplasmin

30 d

2.8 (food)

No significant change

30 d

2.8 (food)

No significant change

30 d

2.33 (fortified food)

Significant decrease in Cu retention

30 d

2.33 (fortified food)

 

6 wk

Not provided

No effect

6 wk

 

Significant decrease in ESOD activityb

1 wk

2.6 (food)

No effect

1 wk

2.6 (food)

No effect

1 wk

2.6 (food)

No effect

1 wk

2.6 (food)

No effect

2 wk

2.6 (food)

Increase in Cu excretion/decrease in retention

12 wk

Not provided

Decrease in ESOD (women only)

10 wk

Not provided

Significant decrease in ESOD activity

8 wk

Not provided

No effect

8 wk

 

Significant decrease in serum Cu

c Boukaiba et al. (1993) is a crossover study designed to determine the effects of low-dose zinc supplementation on food intake, nutritional status, immune and lipid indexes. The 16-week study period was divided into two experimental treatment periods, each lasting 8 weeks. Serum Zn concentrations were depressed.

conate in 18 healthy women (aged 25 to 40 years) for 10 weeks. ESOD activity was significantly lower than pretreatment values. Although no dietary zinc or copper intakes were reported, a level of dietary zinc can be estimated at approximately 10 mg/day for women (aged 19 to 50 years) from the 1988–1994 Third National Health and Nutrition Examination Survey (Appendix Table C-26). A LOAEL of 60 mg/day was calculated by adding the supplemental



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