Same as above.

30,121 medical records from a weighted sample of 31,429 records of hospitalized patients from a population of 2,671,863 nonpsychiatric discharged patients.

51 randomly selected acute care, nonpsychiatric hospitals in New York State, 1984.

17% of adverse events resulting from operations and 37% of other adverse events were due to negligence; 47% of physician errors leading to adverse events were due to negligence.

Leape et al., 1991

Adverse Drug Events

Same as above.

4,031 adult nonobstetric admissions to a stratified random sample of 11 medical and surgical units in two hospitals.

Medical records and reports of hospital staff for 2 tertiary care hospitals in Boston, February to July 1993.

There were 1.8 preventable adverse drugs events (ADEs) per 100 admissions (adjusted rate), of which 20% were life threatening, 43% were serious, and 37% were significant. There were an additional 5.5 potential ADEs per 100 admissions (adjusted rate).

Bates et al., 1995

Same as above.

4,031 patients admitted to 5 intensive care units (3 medical, 2 surgical) and 6 general care units (4 medical, 2 surgical) selected from a stratified random sample of units in 2 tertiary care hospitals in Boston.

Case-investigation reports (including staff interviews, medical record review, etc.) for patients admitted between February and July 1993.

There were 19 preventable or potential ADEs per 1000 patient days in the ICUs. There were 10 preventable or potential ADEs per 1000 patient days in general care units. Rates adjusted for number of medications per patient showed no significant differences for the two settings.

Cullen et al., 1997



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement