. "Appendix C: Time Line of Tobacco Events." Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction. Washington, DC: The National Academies Press, 2001.
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Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction
Science
Products
Policies or Regulation
1854–1856
• Cigarette popularity grows between 1854 and 1856 during the Crimean War
1881
• James Bonsack of Virginia patents the first cigarette-making machine.
1893
• Pictet and Crepieux synthesize nicotine
1900
• Brosch appears to be the first investigator involved in experimental tobacco carcinogenesis. He applies tobacco (“juices”) to guinea pigs, observing epithelial proliferation
1913
• Camel brand is produced by R.J. Reynolds in 1913
1928
• Lombard and Doerring find an association between heavy smoking and buccal cancer
1938
• Pearl, a statistician and biometrician at Johns Hopkins, publishes the first statistical analysis comparing the health of smokers and nonsmokers and finds that individuals who smoked could expect shorter lives
1950
• Epidemiological studies report that lung cancer is particularly prevalent among cigarette smokers
