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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Support for this project was provided by the Food and Drug Administration (FDA) prior to the March 2000 decision by the Supreme Court denying FDA comprehensive authority over tobacco products. The views presented in this report are those of the Institute of Medicine Committee to Assess the Science Base for Tobacco Harm Reduction and are not necessarily those of the funding agencies.

Library of Congress Cataloging-in-Publication Data

Clearing the smoke: assessing the science base for tobacco harm reduction/Kathleen Stratton…[et al.], editors.

p.; cm.

ISBN 0-309-07282-4 (alk. paper: case)

1. Smoking—Health aspects. 2. Smoking cessation programs. 3. Tobacco habit—Prevention.

[DNLM: 1. Tobacco Smoke Pollution—prevention & control. 2. Biological Markers. 3. Environmental Exposure—adverse effects. 4. Neoplasms—etiology. 5. Nicotine—pharmacology. 6. Smoke—adverse effects. QV 137 C6225 2001] I. Title: Assessing the science base for tobacco harm reduction. II. Stratton, Kathleen R.

RA645.T62 C56 2001

362.29'66–dc21

2001002837

ISBN 0-309-07282-4

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Copyright 2001 by the National Academy of Sciences. All rights reserved.

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