Intravenous yeasts (proper-myl). A preparation of cells from three species of yeast. Administered intravenously, proper-myl appears to be ineffective in the treatment of MS.
Pancreatic Extract (Deporpanex). A preparation derived from beef pancreas, given intramuscularly. The exact composition is not known, but it does not contain protein. Due to limited data, this treatment cannot be considered effective in MS. The Committee believes this therapy has been adequately tested and shown to be without value. Risks are undetermined.
Heart and Pancreas Extract (Pancorphen). A weak protein solution prepared by digesting beef heart with hog pancreas. It was used as a culture medium for growing bacteria. Pancorphen appears unacceptable as a treatment for MS as there is no evidence of benefit and evidence of side effects and an adverse effect on MS symptoms. The Committee believes that this therapy should not be used.
Snake Venom (PROven, Venogen, Horvi MS9). Proven is a processed mixture of cobra, krait, and water moccasin venoms for subcutaneous injection. It has had spectrographic analysis. Although its exact composition is not established, it appears to contain many proteins and some of the numerous enzymatic activities of the original venoms used in the mixture. This therapy is not recommended because of lack of evidence of benefit and because of the side effects and danger of allergic reaction.
Honey Bee Venom. Extracts of the bee venom. There are no objective controlled studies. Based on the evidence, this treatment is not recommended. The Committee feels that there is no generally accepted scientific basis for use of this therapy because it never has been tested in a properly controlled trial, and its use carries significant risk.
Octacosanol. A simple long-chain alcohol. The Committee believes that there is no generally accepted scientific basis for use of this therapy and that the risks are undetermined.
Superoxide Dismutase (Orgotein, Orgosein, Palosein). Superoxide dismutase (SOD) is a metalloprotein enzyme that combines with and ”neutralizes“ free radicals of oxygen (superoxides) appearing as a normal toxic byproduct of cellular metabolism. It is available in health food stores as an extract of liver in tablet form and is used in veterinary practice as an anti-inflammatory agent (by injection). The Committee believes there appears to be no generally accepted scientific basis for the use of this therapy.