I have attempted to describe a pain classification system that is substantive when viewed retrospectively. It assumes strong veterinary action in prereview, the design of a pilot, and retrospective adjustment of protocols not only so that accurate reporting is performed, but also so that the public can be made more aware of which relief measures were meaningful. This system of veterinary collaboration, pilot design, and retrospective refinements and reporting affords more efficient experimental conduct with more accurate reporting of results and animal pain classification.
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Unger E.F., S. Banai, M. Shou, D.F. Lazarous, M.T. Jaklitsch, M. Scheinowitz, R. Correa, C.Klingbeil, and S.E. Epstein. 1994. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am J Physiol 299(Pt 2): H1588-H1595.
Unger E.F., C.D. Sheffield, and S.E. Epstein. 1990. Creation of anastomoses between an extracardiac artery and the coronary circulation. Proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium. Circulation 82: 1449-1466.
Unger E.F., C.D. Sheffield, and S.E. Epstein. 1991. Heparin promotes the formation of extracardiac to coronary anastomoses in a canine model. Am J Physiol 260(Pt 2): H1625-H1634.
Unger E.F., M. Shou, C.D. Sheffield, E. Hodge, M. Jaye, and S.E. Epstein. 1996. Extracardiac to coronary anastomoses support regional left ventricular function in dogs. Am J Physiol 264(Pt 2): H1567-1574.