Frontiers of Engineering: Reports on Leading-Edge Engineering From the 2000 NAE Symposium on Frontiers in Engineering

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In summary, this brief overview is intended to provide a sampling of the ways in which studying protein structure and function in the “genomic era” furnishes new challenges and opportunities and is likely to give rise to a host of unexpected and exciting discoveries.

ACKNOWLEDGMENTS

I thank all members of the North East Structural Genomics Consortium, but especially my collaborator at Yale, Mark Gerstein, for his insights and advice on illustrations for my presentation. I acknowledge Christine Orenga and Janet Thornton for the CATH protein classification system and for the illustrations in this article that are taken from their work.

REFERENCES

Balasubramanian, S., T. Schneider, M. Gerstein, and L. Regan. 2000. Proteomics of Mycoplasma.genitaliumi:Identification and characterization of unannotated and atypical proteins in a small model genome. Nucleic Acids Research 28: 3075–3082 and references therein.

Boyer, R. 1999. Concepts in Biochemistry. Pacific Grove, Calif.: Brooks/Cole Publishing Co.

Chothia C., and A. M. Leske. 1986. The relation between the divergence of sequence and structure in proteins. The EMBO Journal 5(4): 823–826.

Orengo, C. A., A. D. Michie, S. Jones, D. T. Jones, M. B. Swindells, and J. M. Thornton. 1997. CATH: A hierarchic classification of protein domain structures. Structure 5(8): 1093–1108.

Teichmann, S. A., C. Chothia, and M. Gerstein. 1999. Advances in structural genomics. Current Opinion in Structural Biology 9: 390–399.

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