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The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine.

Library of Congress Cataloging-in-Publication Data

Science, medicine, and animals / Committee on the Use of Animals in Research

p. cm.

“Prepared for the councils of the National Academy of Sciences and the Institute of Medicine.”

ISBN 0-309-04439-1

1. Animal experimentation. I. Committee on the Use of Animals in Research (U.S.) II. National Academy of Sciences (U.S.)

III. Institute of Medicine (U.S.)

HV49156.S35 1991

619—dc20

90-27785

CIP

Copyright © 1991 by the National Academy of Sciences

No part of this book may be reproduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher, except for the purposes of official use by the United States Government.

Printed in the United States of America

COVER PHOTO:

Photomicrographs of the drug AZT, which was tested and developed in animals for the treatment of AIDS in humans, taken at magnifications of 30x and 50x and illuminated with polarized and darkfield lighting techniques.

PHOTO CREDITS:

National Cancer Institute (cover and pages 3, 5, 6, 8-9, 16, 21, 26, and 27)

Delta Society and People, Pets, Partnership (page 14)



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