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Veterans and Agent Orange: Update 2000 (2001)
Institute of Medicine (IOM)

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. "3 Toxicology." Veterans and Agent Orange: Update 2000. Washington, DC: The National Academies Press, 2001.

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Veterans and Agent Orange: Update 2000

Wei M, Wanibuchi H, Yamamoto S, Li W, Fukushima S. 1999. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. Carcinogenesis 20:1873–1876.

Wei YD, Rannug U, Rannug A. 1999. UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan. Chemico-Biological Interactions 118:127–140.

Willey JJ, Stripp BR, Baggs RB, Gasiewicz TA. 1998. Aryl hydrocarbon receptor activation in genital tubercle, palate and other embryonic tissue in 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice. Toxicology and Applied Pharmacology 151:33–44.

Wittsiepe J, Kullmann Y, Schrey P, Selenka F, Wilhelm M. 1999. Peroxidase-catalyzed in vitro formation of poly chlorinated dibenzo-p-dioxins and dibenzofurans from chlorophenols. Toxicology Letters 106:191–200.

Wolf CJ, Ostby JS, Gray LE Jr. 1999. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring. Toxicological Sciences 51:259–264.

Wolfle D. 1998. Interactions between 2,3,7,8-TCDD and PCBs as tumor promoters: limitations of TEFs. Teratogenesis, Carcinogenesis, and Mutagenesis. 17:217–224.

Wolfle D, Marotzki S, Dartsch D, Schafer W, Marquardt H. 2000. Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis 21:15–21.

Worner W, Schrenk D. 1998. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppreses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes. Environmental Toxicology and Pharmacology 6:239–247.

Wyde ME, Seely J, Lucier GW, Walker NJ. 2000. Toxicity of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in diethylnitrosamine-initiated ovariectomized rats implanted with subcutaneous 17β-estradiol pellets. Toxicological Sciences 54:493–499.

Yamanaka K, Katsumata K, Ikuma K, Hasegawa A, Nakano M, Okada S. 2000. The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice. Cancer Letters 152(1):79– 85.

Yang AL, Smith AG, Akhtar R, Clothier B, Robinson S, MacFarlane M, Festing MFW. 1999. Low levels of p53 are associated with resistance to tetrachlorodibenzo-p-dioxin toxicity in DBA/2 mice. Pharmacogenetics 9:183–188.

Yang JH. 1999. Expression of dioxin-responsive genes in human endometrial cells in culture. Biochemical and Biophysical Research Communications 257:259–263.

Yang JH, Vogel C, Abel J. 1999. A malignant transformation of human cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits altered expressions of growth regulatory factors. Carcinogenesis 20:13–18.

Yang JZ, Agarwal SK, Foster WG. 2000. Subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the pathophysiology endometriosis in the cynomolgus monkey. Toxicological Sciences 56:374–381.


Zaher H, Fernandez-Salguero PM, Letterio J, Sheikh MS, Fornace AJ Jr, Roberts AB, Gonzalez FJ. 1998. The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Molecular Pharmacology 54(2):313–321.

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