TABLE 6-3 Epidemiologic Studies—Veterans’ Exposure

Reference

Study Design

Description

Study Group (N)

Comparison Group (N)a

United States Studies

New Ranch Hand Studies

AFHS, 2000

Cohort

Evaluation of 266 health-related end points, including assessments of 10 clinical areas: general health, neoplasia, neurological, psychological, gastrointestinal, cardiovascular, hematologic, endocrine, immunologic, and pulmonary

995

1,299

Longnecker and Michalek, 2000

Cohort

Based on physical examination and medical record review through 1992, analyzed association between serum dioxin levels and diabetes mellitus among the comparison group (no Ranch Hands)

1,281

1,197

Ketchum et al., 1999

Cohort

Based on physical examination and medical record review through 1992, analyzed association between serum dioxin levels and cancer, skin cancer, and other than skin cancer

1,109

980

922

980

1,493

1,275

1,202

1,275

Michalek et al., 1999a

Cohort

To further elucidate the relationship between dioxin and diabetes mellitus, this analysis studies the effect of dioxin body burden on the relationship between sex hormone-binding globulin and insulin and fasting glucose

952

871

1,281

1,121

Michalek et al., 1999b

Cohort

Based on physical examinations in 1982, 1985, 1987, and 1992, examination of immunologic response and exposure to dioxin among Ranch Hand and comparison cohorts

952

914

372

358

1,281

1,186

491

456



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