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Contents

Executive Summary 1
Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism 13
    Origins of the Immunization Safety Review Project 14
    The Charge to the Committee 15
    The Study Process 16
    The Framework for Assessing Causality 17
    Under Review: The MMR–Autism Hypothesis 18
    Plausibility Assessment 21
    Causality Argument 44
    Significance Assessment 46
    Recommendations 55
    Summary 60
    References 60
Appendix A 71
Appendix B 75
Appendix C 79
Appendix D 85


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