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equal attention. For decades, physicians and researchers have known that environmental contaminants—radioactive wastes, heavy metals, toxic chemicals, and so on—play a role in human diseases, including cancers, neurodegenerative disorders, and birth defects. But the threat posed by these contaminants has proved complex and difficult to resolve. On the environmental side, for instance, cleaning up contamination is often frustrating and expensive, especially when the contaminants are spread through many square miles of ground and in large underground aquifers, as in large-scale contaminated sites. On the human-health side, how a person's body responds to an environmental insult depends heavily on the person's genes, and there is some degree of variation from person to person in vulnerability to environmental contaminants. That variability complicates the analysis, treatment, and prevention of environmentally triggered diseases, and scientists often find it difficult to answer even such seemingly simple questions as whether a cluster of cancers in one small geographic area occurred by chance or was caused by exposure to some environmental carcinogen.

The coming flood of genomic information could change all that. Environmental cleanup, for example, might be greatly aided by the ability to genetically engineer plants and bacteria to remove some contaminants from soil and water. On the medical front, researchers believe that having the complete human genome to work with might help them understand how environmental contaminants lead to cancers and other diseases and to figure out why some people are more susceptible than others. Ultimately, both prevention and treatment could be transformed by the insights that stem from genomic information.

The genomic revolution can also be expected to have ramifications outside science and medicine. It might have consequences, for example, for the court system, where citizens and corporations go to determine who has been harmed by environmental contamination, who is at fault, and how much compensation is owed for the harm. Judges and juries are already straining to comprehend the scientific evidence in some cases; how will they respond to a deluge of new, complex information that they must digest to reach a verdict? The new, more complete genomic information that is coming will once again raise the issue of genetic discrimination in hiring decisions and health insurance. Should the government, for instance, allow companies to use information about a person's susceptibilities to environmental contaminants in hiring and insurance decisions? And how might the new genomic information change how people think of disease? If it becomes possible to trace the development of a disease from the first environmental insult through each of the intermediate stages to the point where it can be identified as a recognizable syndrome, then disease might come to be seen not in terms of black and white or off and on, but as one end of a spectrum.

Because of the importance of this complex set of issues, and because they have seldom been analyzed as a whole instead of as separate pieces, on August 16, 2000, the National Academies' Board on Life Sciences held a one-day forum, “Environmental Contamination, Biotechnology, and the Law: The Impact



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