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velopment and production. The Army must be able to respond to threats with vaccines and antibiotics in weeks rather than years. As the pace of genomics advances quickens, the Army will be hard pressed to take advantage of the many opportunities for providing better vaccines more quickly. Reducing the time involved in clinical trials, which routinely involve large populations, should be a high priority.

Recommendation 8a. The Army should build on its strengths in the development of vaccines by funding new technological approaches that could shorten the time for the development and production of vaccines in response to observed pathogens. These include engineered virus-based vaccines and other genomics developments, such as DNA vaccines, cell-based vaccines, and monoclonal antibodies.

Recommendation 8b. The Army should explore (1) using transgenics to shorten the clinical trial phase for defining toxicity and (2) using pharmacogenomics to shorten the time for Phase III clinical trials.