Page ix

Contents

EXECUTIVE SUMMARY 1
    Introduction, 1
    Identifying Health Problems, 1
    Treatment Effectiveness, 3
    Condition-Specific Treatments, 6
    Conclusion, 7
1     INTRODUCTION 11
    Background, 12
    Clinical Registries, 13
    Summary of Gulf War Reports and Evaluations, 14
    Gulf War Veterans' Health: Research Summary, 18
    Ongoing Clinical Research, 19
    War-Related Illnesses and Postdeployment Health Research, 20
2     IDENTIFYING CONDITIONS FOR STUDY 23
3     DETERMINING TREATMENT EFFECTIVENESS 31
    Study Designs and Strength of Inference, 31
    Efficacy Versus Effectiveness, 34
    Outcomes Research, 35
    Meta-Analysis, 36
    Levels of Evidence for Efficacy and Effectiveness Research, 37
    Specific Levels of Evidence or Weights, 38
    Other Considerations, 40
    Recommendations, 41


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