TABLE 6–1 Signs and Symptoms Reported to Be Related to Aircraft Cabin Air

Reported Signs and Symptoms

Respiratory and Mucosal Surfaces

Neurological and Neurobehavioral

Syndrome-Symptom Complexes

Other Symptoms

Health Outcomes

Irritation, pain (eyes, nose, sinuses, throat)

Difficulty breathing

Breathing discomfort

Pain in chest


Dry, stuffy nose

Neurotoxicity (altered vision and coordination, loss of balance, slurred speech, paresthesias)

Neurobehavioral (impaired memory and ability to concentrate, trouble counting, general cognitive problems)


Disorientation and confusion



Weakness and fatigue

Feelings of intoxication

Aerotoxic syndrome

Irritability, neurotoxicity, chemical sensitivity

Acute intoxications

Neurological signs and symptoms, neurobehavioral effects, cardiovascular effects, gastrointestinal symptoms

Chemical sensitivity


Cough, chest discomfort, irritation of mucous membranes

Organophosphate-induced delayed neuropathy syndrome

Delayed-onset weakness, ataxia, paralysis

Dry skin

Rapid heart rate and palpitations

Reproductive effects Cancer (unrelated to cosmic radiation)

Lung function effects

Signs and symptoms related to underlying disease or episodes of worsening underlying diseases (cardiovascular, chronic respiratory)

Signs and symptoms related to cabin pressure and oxygen content

Acute infections (1979 influenza outbreak, tuberculosis)


Hair loss

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