TABLE 4 Developmental Capacity of Cytoplasts Reconstituted by Nuclei from Fetal and Adult Somatic Cells

1

2

3

4

Species

Recipient cytoplast

Donor Cell Type

% Early Development: % Blastocyst (# Blastocysts/ # Cultured)

Mouse

Zygote Mll oocyte

Cumulus Cell Thymocyte

0 (0/91) 7% (6/88)

Cumulus Cell

67% (101/151)

Neuronal Cell

22% (50/223)

Sertoli cell (mature)

40% (63/159)

Cumulus Cell

20% (19/93)

Cultured follicular cell;

34% (51/151) 3% (1/30)

Adult Male fibroblast;

50% (207/414)

Cumulus cell.

52% (206/393)

Fibroblast cell

23% (38/162)

Sertoli Cell (immature)

33% (94/284)

Sheep

Mll oocyte

Fetal fibroblast

27% (34/124)

Adult Mammary (epithelial)

12% (29/247)

Transgenic Fetal fibroblast

5-21% (5/82-19/89)

Transgenic Fetal fibroblast

6-28% (14/109, 43/154, 4/71, 19/83)

Cattle

Mll oocyte

Cumulus cell

13% (5/38)

Fetal fibroblast

12% (33/276)



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