National Academies Press: OpenBook

Neural Signaling (2002)

Chapter: Front Matter

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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Neural Signaling

Arthur M.Sackler COLLOQUIA OF THE NATIONAL ACADEMY OF SCIENCES

National Academy of Sciences
Washington, D.C.

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
×

Arthur M. Sackler, M.D.

1913–1987

Born in Brooklyn, New York, Arthur M.Sackler was edu cated in the arts, sciences, and humanities at New York University. These interests remained the focus of his life, as he became widely known as a scientist, art collector, and philanthropist, endowing institutions of learning and culture throughout the world.

He felt that his fundamental role was as a doctor, a vocation he decided upon at the age of four. After completing his internship and service as house physician at Lincoln Hospital in New York City, he became a resident in psychiatry at Creedmoor State Hospital. There, in the 1940s, he started research that resulted in more than 150 papers in neuroendocrinology, psychiatry, and experimental medicine. He considered his scientific research in the metabolic basis of schizophrenia his most significant contribution to science and served as editor of the Journal of Clinical and Experimental Psychobiology from 1950 to 1962. In 1960 he started publication of Medical Tribune, a weekly medical newspaper that reached over one million readers in 20 countries. He established the Laboratories for Therapeutic Research in 1938, a facility in New York for basic research that he directed until 1983.

As a generous benefactor to the causes of medicine and basic science, Arthur Sackler built and contributed to a wide range of scientific institutions: the Sackler School of Medicine established in 1972 at Tel Aviv University, Tel Aviv, Israel; the Sackler Institute of Graduate Biomedical Science at New York University, founded in 1980; the Arthur M.Sackler Science Center dedicated in 1985 at Clark University, Worcester, Massachusetts; and the Sackler School of Graduate Biomedical Sciences, established in 1980, and the Arthur M.Sackler Center for Health Communications, established in 1986, both at Tufts University, Boston, Massachusetts.

His pre-eminence in the art world is already legendary. According to his wife Jillian, one of his favorite relaxations was to visit museums and art galleries and pick out great pieces others had overlooked. His interest in art is reflected in his philanthropy; he endowed galleries at the Metropolitan Museum of Art and Princeton University, a museum at Harvard University, and the Arthur M.Sackler Gallery of Asian Art in Washington, DC. True to his oft-stated determination to create bridges between peoples, he offered to build a teaching museum in China, which Jillian made possible after his death, and in 1993 opened the Arthur M.Sackler Museum of Art and Archaeology at Peking University in Beijing.

In a world that often sees science and art as two separate cultures, Arthur Sackler saw them as inextricably related. In a speech given at the State University of New York at Stony Brook, Some reflections on the arts, sciences and humanities, a year before his death, he observed: “Communication is, for me, the primum movens of all culture. In the arts…I find the emotional component most moving. In science, it is the intellectual content. Both are deeply interlinked in the humanities.” The Arthur M.Sackler Colloquia at the National Academy of Sciences pay tribute to this faith in communication as the prime mover of knowledge and culture.

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
×

PNAS

Proceedings of the National Academy of Sciences of the United States of America

Contents

Papers from the Inaugural Arthur M.Sackler Colloquium of the National Academy of Sciences

 

 

INTRODUCTION

 

 

   

Arthur M.Sackler and science
Solomon H.Snyder

 

1

 

 

COLLOQUIUM PAPERS

 

 

   

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase
David E.Baranano and Solomon H.Snyder

 

3

   

Presynaptic kainate receptors at hippocampal mossy fiber synapses
Dietmar Schmitz, Jack Mellor, Matthew Frerking, and Roger A.Nicoll

 

10

   

Retrograde signaling at central synapses
Huizhong W.Tao and Mu-ming Poo

 

16

   

Controlling potassium channel activities: Interplay between the membrane and intracellular factors
B.Alexander Yi, Daniel L.Minor, Jr., Yu-Fung Lin, Yuh Nung Jan, and Lily Yeh Jan

 

23

   

Calcium regulation of neuronal gene expression
Anne E.West, Wen G.Chen, Matthew B.Dalva, Ricardo E.Dolmetsch, Jon M.Kornhauser, Adam J.Shaywitz, Mari A.Takasu, Xu Tao, and Michael E.Greenberg

 

31

   

Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans
Erin L.Peckol, Emily R.Troemel, and Cornelia I.Bargmann

 

39

   

Presenilin, Notch, and the genesis and treatment of Alzheimer’s disease
Dennis J.Selkoe

 

46

   

∆FosB: A sustained molecular switch for addiction
Eric J.Nestler, Michel Barrot, and David W.Self

 

49

   

Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Raul R.Gainetdinov, Amy R.Mohn, Laura M.Bohn, and Marc G.Caron

 

54

   

Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity
Pat Manzerra, M.Margarita Behrens, Lorella M.T.Canzoniero, Xue Qing Wang, Valérie Heidinger, Tomomi Ichinose, Shan Ping Yu, and Dennis W.Choi

 

62

   

Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
Feng Liu, Xiao-Hong Ma, Jernej Ule, James A.Bibb, Akinori Nishi, Anthony J. DeMaggio, Zhen Yan, Angus C.Nairn, and Paul Greengard

 

69

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
×

Arthur M.Sackler COLLOQUIA OF THE NATIONAL ACADEMY OF SCIENCES

Neural Signaling

February 15-17, 2001

National Academy of Sciences, Washington, DC

Organized by Solomon H.Snyder, M.D., and Richard L.Huganir, Ph.D.

Program

Thursday, February 15

Inaugural Sackler Lecture

Solomon H.Snyder, Johns Hopkins University

Brain Messengers

Friday, February 16

Introductory Remarks

Solomon H.Snyder

Session I. Inter- and Intracellular Signaling in the Nervous System

Chair, Solomon H.Snyder

Pietro DeCamilli, Yale University

Molecular Mechanisms in Synaptic Vesicle Endocytosis and Recycling

Richard L Huganir, Howard Hughes Medical Institute, Johns Hopkins University

AMPA Receptors and Synaptic Plasticity

Roger Nicoll, University of California, San Francisco

The Brain's Own Cannabis

Mu-ming Poo, University of California, Berkeley

Retrograde Signaling Associated with LTP/LTD

Session II. Inter- and Intracellular Signaling in the Nervous System (continued)

Chair, Richard L.Huganir

Lily Jan, University of California, San Francisco

Molecular Regulation of Ion Channels

Michael Greenberg, Harvard University

Signal Transduction Pathways that Regulate Nervous System Development and Function

Cori Bargmann, University of California, San Francisco

Olfactory Diversity and Olfactory Behavior: A Novel Lateral Signaling Pathway that Requires Axon Contact and Calcium Signaling

Dennis Selkoe, Harvard University

Presenilin, Notch and the Genesis and Treatment of Alzheimer's Disease

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
×

Saturday, February 17

Session III. Signaling in the Developing Nervous System

Chair, Cori Bargmann

Richard Axel, Columbia University

Establishing and Maintaining an Olfactory Sensory Map

Marc Tessier-Lavigne, University of California, San Francisco

Signaling in Axon Growth and Guidance

Corey Goodman, University of California, Berkeley

Wiring Up the Brain: Genes, Gradients, and Growth Cones

Carla Shatz, Harvard University

Nature and Nurture in Brain Wiring

Session IV. Drugs and Disease and Signaling in the Nervous System

Chair, Lily Jan

Eric Nestler, Dallas Southwestern Medical School

Molecular Basis of Drug Addiction

Marc Caron, Duke University

Interplay Between Dopamine, Glutamate and Serotonin Systems in Mice Lacking the Dopamine Transporter

Dennis Choi, Washington University

Zinc-Mediated Neural Signaling

Paul Greengard, Rockefeller University

The Neurobiology of Dopamine Signaling

Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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Suggested Citation:"Front Matter." National Academy of Sciences. 2002. Neural Signaling. Washington, DC: The National Academies Press. doi: 10.17226/10300.
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