Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.
OCR for page R1
Neural Signaling: Arthur M. Sackler Colloquia of the National Academy of Sciences Neural Signaling Arthur M.Sackler COLLOQUIA OF THE NATIONAL ACADEMY OF SCIENCES National Academy of Sciences Washington, D.C.
OCR for page R2
Neural Signaling: Arthur M. Sackler Colloquia of the National Academy of Sciences Arthur M. Sackler, M.D. 1913–1987 Born in Brooklyn, New York, Arthur M.Sackler was edu cated in the arts, sciences, and humanities at New York University. These interests remained the focus of his life, as he became widely known as a scientist, art collector, and philanthropist, endowing institutions of learning and culture throughout the world. He felt that his fundamental role was as a doctor, a vocation he decided upon at the age of four. After completing his internship and service as house physician at Lincoln Hospital in New York City, he became a resident in psychiatry at Creedmoor State Hospital. There, in the 1940s, he started research that resulted in more than 150 papers in neuroendocrinology, psychiatry, and experimental medicine. He considered his scientific research in the metabolic basis of schizophrenia his most significant contribution to science and served as editor of the Journal of Clinical and Experimental Psychobiology from 1950 to 1962. In 1960 he started publication of Medical Tribune, a weekly medical newspaper that reached over one million readers in 20 countries. He established the Laboratories for Therapeutic Research in 1938, a facility in New York for basic research that he directed until 1983. As a generous benefactor to the causes of medicine and basic science, Arthur Sackler built and contributed to a wide range of scientific institutions: the Sackler School of Medicine established in 1972 at Tel Aviv University, Tel Aviv, Israel; the Sackler Institute of Graduate Biomedical Science at New York University, founded in 1980; the Arthur M.Sackler Science Center dedicated in 1985 at Clark University, Worcester, Massachusetts; and the Sackler School of Graduate Biomedical Sciences, established in 1980, and the Arthur M.Sackler Center for Health Communications, established in 1986, both at Tufts University, Boston, Massachusetts. His pre-eminence in the art world is already legendary. According to his wife Jillian, one of his favorite relaxations was to visit museums and art galleries and pick out great pieces others had overlooked. His interest in art is reflected in his philanthropy; he endowed galleries at the Metropolitan Museum of Art and Princeton University, a museum at Harvard University, and the Arthur M.Sackler Gallery of Asian Art in Washington, DC. True to his oft-stated determination to create bridges between peoples, he offered to build a teaching museum in China, which Jillian made possible after his death, and in 1993 opened the Arthur M.Sackler Museum of Art and Archaeology at Peking University in Beijing. In a world that often sees science and art as two separate cultures, Arthur Sackler saw them as inextricably related. In a speech given at the State University of New York at Stony Brook, Some reflections on the arts, sciences and humanities, a year before his death, he observed: “Communication is, for me, the primum movens of all culture. In the arts…I find the emotional component most moving. In science, it is the intellectual content. Both are deeply interlinked in the humanities.” The Arthur M.Sackler Colloquia at the National Academy of Sciences pay tribute to this faith in communication as the prime mover of knowledge and culture.
OCR for page R3
Neural Signaling: Arthur M. Sackler Colloquia of the National Academy of Sciences PNAS Proceedings of the National Academy of Sciences of the United States of America Contents Papers from the Inaugural Arthur M.Sackler Colloquium of the National Academy of Sciences INTRODUCTION Arthur M.Sackler and science Solomon H.Snyder 1 COLLOQUIUM PAPERS Neural roles for heme oxygenase: Contrasts to nitric oxide synthase David E.Baranano and Solomon H.Snyder 3 Presynaptic kainate receptors at hippocampal mossy fiber synapses Dietmar Schmitz, Jack Mellor, Matthew Frerking, and Roger A.Nicoll 10 Retrograde signaling at central synapses Huizhong W.Tao and Mu-ming Poo 16 Controlling potassium channel activities: Interplay between the membrane and intracellular factors B.Alexander Yi, Daniel L.Minor, Jr., Yu-Fung Lin, Yuh Nung Jan, and Lily Yeh Jan 23 Calcium regulation of neuronal gene expression Anne E.West, Wen G.Chen, Matthew B.Dalva, Ricardo E.Dolmetsch, Jon M.Kornhauser, Adam J.Shaywitz, Mari A.Takasu, Xu Tao, and Michael E.Greenberg 31 Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans Erin L.Peckol, Emily R.Troemel, and Cornelia I.Bargmann 39 Presenilin, Notch, and the genesis and treatment of Alzheimer’s disease Dennis J.Selkoe 46 ∆FosB: A sustained molecular switch for addiction Eric J.Nestler, Michel Barrot, and David W.Self 49 Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter Raul R.Gainetdinov, Amy R.Mohn, Laura M.Bohn, and Marc G.Caron 54 Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity Pat Manzerra, M.Margarita Behrens, Lorella M.T.Canzoniero, Xue Qing Wang, Valérie Heidinger, Tomomi Ichinose, Shan Ping Yu, and Dennis W.Choi 62 Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors Feng Liu, Xiao-Hong Ma, Jernej Ule, James A.Bibb, Akinori Nishi, Anthony J. DeMaggio, Zhen Yan, Angus C.Nairn, and Paul Greengard 69
OCR for page R4
Neural Signaling: Arthur M. Sackler Colloquia of the National Academy of Sciences Arthur M.Sackler COLLOQUIA OF THE NATIONAL ACADEMY OF SCIENCES Neural Signaling February 15-17, 2001 National Academy of Sciences, Washington, DC Organized by Solomon H.Snyder, M.D., and Richard L.Huganir, Ph.D. Program Thursday, February 15 Inaugural Sackler Lecture Solomon H.Snyder, Johns Hopkins University Brain Messengers Friday, February 16 Introductory Remarks Solomon H.Snyder Session I. Inter- and Intracellular Signaling in the Nervous System Chair, Solomon H.Snyder Pietro DeCamilli, Yale University Molecular Mechanisms in Synaptic Vesicle Endocytosis and Recycling Richard L Huganir, Howard Hughes Medical Institute, Johns Hopkins University AMPA Receptors and Synaptic Plasticity Roger Nicoll, University of California, San Francisco The Brain's Own Cannabis Mu-ming Poo, University of California, Berkeley Retrograde Signaling Associated with LTP/LTD Session II. Inter- and Intracellular Signaling in the Nervous System (continued) Chair, Richard L.Huganir Lily Jan, University of California, San Francisco Molecular Regulation of Ion Channels Michael Greenberg, Harvard University Signal Transduction Pathways that Regulate Nervous System Development and Function Cori Bargmann, University of California, San Francisco Olfactory Diversity and Olfactory Behavior: A Novel Lateral Signaling Pathway that Requires Axon Contact and Calcium Signaling Dennis Selkoe, Harvard University Presenilin, Notch and the Genesis and Treatment of Alzheimer's Disease
OCR for page R5
Neural Signaling: Arthur M. Sackler Colloquia of the National Academy of Sciences Saturday, February 17 Session III. Signaling in the Developing Nervous System Chair, Cori Bargmann Richard Axel, Columbia University Establishing and Maintaining an Olfactory Sensory Map Marc Tessier-Lavigne, University of California, San Francisco Signaling in Axon Growth and Guidance Corey Goodman, University of California, Berkeley Wiring Up the Brain: Genes, Gradients, and Growth Cones Carla Shatz, Harvard University Nature and Nurture in Brain Wiring Session IV. Drugs and Disease and Signaling in the Nervous System Chair, Lily Jan Eric Nestler, Dallas Southwestern Medical School Molecular Basis of Drug Addiction Marc Caron, Duke University Interplay Between Dopamine, Glutamate and Serotonin Systems in Mice Lacking the Dopamine Transporter Dennis Choi, Washington University Zinc-Mediated Neural Signaling Paul Greengard, Rockefeller University The Neurobiology of Dopamine Signaling