food/fluid intake, fever and respiratory embarrassment

 

Burstein & Fleischer (1994)

Case-control

54 case children, age 3– 36 months, participating in multicenter antibiotic study and 108 age-matched controls (United States)

Vaccination history, including DTwP, obtained from medical records. Hib not yet available for these children

Children with occult bacterimia: S. pneumoniae, E. coli, S. aureus, H. influenzae, or Salmonella spp

Difference between cases and controls NS (p>0.05)

Interval (days) since last Vaccine

Cases=128.8+/-111.5

Febrile=154.9+/-99.6

Trauma=163.0+/-157.8

Interval (days) since last DTwP vaccine

Cases=161.5+/-134

Febrile=188.8+/-128.8

Trauma=184.1+/-172.1

Specific vaccines, other than DTwP, administered to children are unknown.; weak statistical power

Weak evidence relevant to causality; favors no effect of vaccines or of DTwP vaccine

Griffin et al. (1992)

Cohort

64,591 children immunized through Tennessee county health clinics

At least one DTP vaccination in 1986 or 1987; exposure based on information in linked TN immunization-birth certificate database

Invasive bacterial infections (H. influenzae, N .meningitidis, Streptococcus pneumoniae, group B Streptococcus, or Listeria monocytogenes. in children 72 mos. or younger, from surveillance of hospital infection control

Age-adjusted RR (95% CI) Of all invasive bacterial infections by days since DTP immunization

Comparing early post-immunization periods (0–7, 8– 14, 15–28 days) to later period (29+days):

0–7 days: 1.0(0.5–2.0)

8–14 days: 0.8 (0.4–1.7)

15–28 days: 1.2(0.7–1.9)

No unvaccinated comparison group; analysis limited to cases of serious culture-confirmed cases

Weak evidence relevant to causality; favors no effect of DTP vaccine



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