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The Anthrax Vaccine: Is it Safe? Does it Work?
DoD should pursue and encourage research to map the epitopes of the protective antigen that correlate with specific functional activities;
DoD should pursue and encourage research to test the therapeutic potential of antitoxin proteins or antibodies; and
DoD should pursue and encourage research into additional potential virulence factors inB. anthracisand into other possible vaccine candidates.
REFERENCES
Pittman PR, Kim-Ahn G, Pifat DY, Coonan K, Gibbs P, Little S, Pace-Templeton JG, Myers R, Parker GW, Friedlander AM. 2002. Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans . Vaccine 20(9-10):1412-1420.
Schwartz B. 2002. Hypothesis testing using the DMSS: outline for a CDC-AMSA collaboration. Presentation to the Institute of Medicine Committee to Review the CDC Anthrax Vaccine Safety and Efficacy Research Program, Meeting V, Washington, D.C.
