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Marine Biotechnology in the Twenty-First Century: Problems, Promise, and Products
genomics, and proteomics to new “model” species of marine origin; and application of molecular biology to the synthesis of novel marine bioproducts. Use of these technologies should also foster sustainability and provide alternatives to the continued harvest of marine organisms.
New paradigms should be developed for detecting marine natural products and biomaterials as potential pharmaceuticals, biopolymers, and biocatalysts, and for understanding how they exert their biological properties. Updated high throughput methods will need to be developed, adapted, and used to ensure that the testing is done in a timely fashion. In order to maximize the potential for commercial application, new strategies, such as DNA microarrays, mechanism-based profiling screens, integrated pharmacology, and increasingly sophisticated chemical ecology studies are needed for rapidly determining the mechanisms of action of new marine bioproducts. Access to updated and expanded biomedical screening programs is needed in a variety of therapeutic areas, involving broadly coordinated groups of investigators and novel strategies for the rapid identification of chemicals of biomedical importance.
Better tools should be developed for using marine biotechnology to help solve environmental problems such as biofouling, pollution, ecosystem degradation, and hazards to human health.
Greater emphasis should be given to research efforts that seek to commercialize marine bioproducts and assays for medical and environmental applications. Bringing these advances to commercialization will require stronger partnerships between scientists, the public, and innovative small companies. Fostering such partnerships, facilitating technology transfer, and streamlining government regulatory requirements will be needed for marine biotechnology to achieve its full potential.