TABLE 3 Marine-Derived Antitumor Compounds Licensed for Development

Marine Source



Current Status



Discodermia dissoluta

To enter Phase I trials in 2002; licensed to Novartis

Isohomo-halichondrin B

Lissodendoryx sp.

Licensed to PharmaMar S.A.; in advanced preclinical trials


Jaspis sp.

Synthetic derivative licensed to Novartis; in clinical trials

Hemiasterlins A & B

Cymbastella sp.

Derivatives to enter clinical trials in 2002; licensed to Wyeth-Ayerst


Pseudaxinyssa cantharella

Licensed to Rhone Poulenc


Bryostatin 1

Bugula neritina

In Phase I/II clinical trials in U.S./Europe; U.S. National Cancer Institute (NCI) sponsored trials

tion of the resource (see Rosenthal, p. 91 in this report). In all cases, commercial development from natural populations of marine organisms must be sustainable if it is to make economic sense. Sustainability is one of the central challenges in further development of marine biotechnology, and it must be addressed before large-scale marine harvests can begin. Innovative approaches to partnerships between stakeholders can help to support access to marine resources and to ensure their development as sustainable assets. Agreements that include training and education of local populations can be particularly valuable for long-term resource sustainability.

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