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Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
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PLATE 1 Section of the model heart through the left ventricle in diastole. Structures at the top (from left to right in the figure) are pulmonary artery, aorta, and left atrium (with two pulmonary veins appearing in the section). At the bottom (from left to right in the figure), are the right and left ventricles. The anterior and posterior leaflets of the mitral valve appear in cross section at the top of the left ventricle. Note the prominent vortex (rotating clockwise in the figure) that has been shed from the anterior leaflet of the mitral valve, and the less prominent counter-rotating vortex that has been shed from the posterior leaflet. Together these are presumably the cross section of a ring vortex that has been shed like a smoke-ring from the mitral valve as a whole. Reprinted with permission from Kovacs, S.J., D.M. McQueen, and C.S. Peskin. Modeling cardiac fluid dynamics and diastolic function. Phil. Trans. R. Soc. Lond. A 359:1299-1314, 2001.

Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
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PLATE 2 Cutaway view of the model heart showing the flow pattern of blood in the right ventricle during diastole. Structures seen from left to right in the upper part of the figure are the superior vena cava connecting to the right atrium with the interior vena cava below, the aorta, and the pulmonary artery. In the lower part of the figure, a prominent vortex (rotating counterclockwise in the figure) fills the right ventricle. A jet of blood flowing through the open tricuspid valve merges with and presumably drives this vortex. Reprinted with permission from Kovacs, S.J., D.M. McQueen, and C.S. Peskin. Modeling cardiac fluid dynamics and diastolic function. Phil. Trans. R. Soc. Lond. A 359:1299-1314, 2001.

Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
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PLATE 3 Microarray construction. Figure courtesy of Terry Speed.

PLATE 4 Estimates of zone effects: log (zone 4/zone 1) versus average A. Figure courtesy of Terry Speed.

Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
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Page 37
Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
×
Page 38
Suggested Citation:"Color Plates." National Research Council. 2002. Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems. Washington, DC: The National Academies Press. doi: 10.17226/10356.
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Page 39
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 Making Sense of Complexity: Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems
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On April 26-28, 2001, the Board on Mathematical Sciences and Their Applications (BMSA) and the Board on Life Sciences of the National Research Council cosponsored a workshop on the dynamical modeling of complex biomedical systems. The workshop's goal was to identify some open research questions in the mathematical sciences whose solution would contribute to important unsolved problems in three general areas of the biomedical sciences: disease states, cellular processes, and neuroscience. The workshop drew a diverse group of over 80 researchers, who engaged in lively discussions.

To convey the workshop's excitement more broadly, and to help more mathematical scientists become familiar with these very fertile interface areas, the BMSA appointed one of its members, George Casella, of the University of Florida, as rapporteur. He developed this summary with the help of two colleagues from his university, Rongling Wu and Sam S. Wu, assisted by Scott Weidman, BMSA director.

This summary represents the viewpoint of its authors only and should not be taken as a consensus report of the BMSA or of the National Research Council.

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