topic (102). Another question is how cargo and KIF dissociate. To enable cargo proteins to function properly, this dissociation is indispensable.

Concerning how each KIF recognizes and binds to their specific cargo molecules, one significant method is the formation of a receptor-adaptor (scaffold/scaffolding protein)-motor complex as in the case of KIF3, KIF17, and KIF13A (8, 9, 63). Alternatively, KIFs can bind to membrane proteins through light chains (49, 50). These adaptor proteins may contribute in increasing the variety of cargoes a KIF can convey. Thus, it is rapidly becoming clear that the cell uses a number of KIFs and tightly controls the direction, destination, and velocity of transports for various important functional molecules.

We are grateful to members of the Hirokawa laboratory, especially Dr. T.Nakagawa. This work was supported by a grant for Center of Excellence (COE) from the Ministry of Education, Science, and Culture (to N.H).

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Front Matter (R1-R4)

Introduction: Molecular kinesis in cellular function and plasticity (1-2)

Kinesin molecular motors: Transport pathways, receptors, and human disease (3-7)

All kinesin superfamily protein, KIF, genes in mouse and human (8-15)

Assembly and transport of a premessenger RNP particle (16-21)

Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome (22-28)

Spatial and temporal control of RNA stability (29-32)

Molecular mechanisms of translation initiation in eukaryotes (33-40)

The target of rapamycin (TOR) proteins (41-48)

The physiological significiance of ß-actin mRNA localization in determining cell polarity and directional motility (49-54)

Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture (55-61)

Molecular organization of the postsynaptic specialization (62-65)

A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites (66-72)

Think globally, translate locally: What mitotic spindles and neuronal synapses have in common (73-75)

Vasopressin mRNA localization in nerve cells: Characterization of cis-acting elements and trans-acting factors (76-83)

Local translation of classes of mRNAs that are targeted to neuronal dendrites (84-89)

Cytoskeletal microdifferentiation: A mechanism for organizing morphological plasticity in dendrites (90-96)

Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation (97-104)

Synaptic regulation of protein syntesis and the fragile X protein (105-110)

Proceedings program (111-112)