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  1. The various proteins behave differently during RNA transport: some leave the transcript in the nucleoplasm or at the nuclear pore, others are shed subsequent to the translocation of the particle through the nuclear pore, whereas still others accompany the mRNA into polysomes.

  2. The flow pattern of a protein seems related to the function of the protein.

  3. The particle proteins exert specific mRNA-related functions rather than merely serving as RNA-packaging devices.

  4. The cotranscriptional assembly process sets the stage for both the nuclear and the cytoplasmic fate of the mRNA sequence.

I thank Sergej Masich, Birgitta Björkroth, and Birgitta Ivarsson for preparing the figures. The research was supported by the Swedish Natural Science Research Council, the Human Frontier Science Program Organization, the Knut and Alice Wallenberg Foundation, the Marianne and Marcus Wallenberg Foundation, and the Gunvor and Josef Anér Foundation.

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