Proposed Framework for Evaluating the Safety of Dietary Supplements -- For Comment

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Proposed Framework for Evaluating the Safety of Dietary Supplements -- For Comment (2002)
Food and Nutrition Board (FNB)
Institute of Medicine (IOM)
Board on Life Sciences (BLS)

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. "Appendix C Possible Combinations of Scores." Proposed Framework for Evaluating the Safety of Dietary Supplements -- For Comment. Washington, DC: The National Academies Press, 2002.

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For Comment: Proposed Framework for Evaluating the Safety of Dietary Supplements

Priority Group	Human Data	Animal Data	Structure Data	In Vitro Data
V	0	1	1	2
	0	1	1	NAD
	0	1	1	1
	0	1	1	0
	0	1	0	2
	0	1	0	NAD
	0	1	0	1
	0	1	0	0
	0	0	2	2
	0	0	2	NAD
	0	0	2	1
	0	0	2	0
	0	0	NAD	2
	0	0	NAD	NAD
	0	0	NAD	1
	0	0	NAD	0
	0	0	1	2
	0	0	1	NAD
	0	0	1	1
	0	0	1	0
	0	0	0	2
	0	0	0	NAD
	0	0	0	1
	0	0	0	0

Page
137

Front Matter (R1-R12)

Executive Summary (1-12)

1 Introduction and Background (13-28)

2 Approaches Used by Others to Consider Dietary Supplement Safety and Other Existing Safety Frameworks (29-38)

3 Outline of the Overall Process for Evaluation of Dietary Supplement Ingredients (39-46)

4 Factors Considered in Screening, Setting Priorities, and Safety Evaluation (47-76)

5 Framework Steps One and Two: Screening/Flagging and Priority Setting (77-90)

6 Framework Step 3: Critical Safety Evaluation of Dietary Supplement Ingredients (91-98)

7 Attributes and Limitations of the Proposed Framework (99-102)

8 Dietary Supplement Ingredients Selected for Prototype Safety Monographs (103-105)

Appendix A Other Approaches to Considering the Safety of Dietary Supplements (106-115)

Appendix B Existing Frameworks of Systems for Evaluating the Safety of Other Substances (116-123)

Appendix C Possible Combinations of Scores (124-137)

Appendix D Table of Food and Drug Administration Actions on Dietary Supplements (138-139)

Appendix E Presenters at the Open Sessions of the Project on the Framework for Evaluating the Safety of Dietary Supplements (140-140)

Appendix F Biographical Sketches of Committee Members (141-144)