Appendix F
Biographical Sketches of Committee Members

Barbara O.Schneeman, Ph.D. (chair) served formerly as dean, College of Agricultural and Environmental Sciences, and currently serves as a professor of nutrition in the Department of Nutrition and in the Division of Clinical Nutrition and Metabolism, University of California at Davis. Her professional activities include membership on the U.S. Department of Agriculture (USDA)/Department of Health and Human Services 1990 and 1995 Dietary Guidelines for Americans Advisory Committees, the Board of Trustees of the International Life Sciences Institute, and the editorial boards of Proceedings of the Society of Experimental Biology and Medicine, Food and Nutrition Series of Academic Press, Nutrition Reviews, Journal of Nutrition, and California Agriculture. Professional honors include the Institute of Food Technologists’ Samuel Gate Prescott Award for research, the Commissioner’s Special Citation, and the Harvey W.Wiley Medal from the Food and Drug Administration (FDA) in recognition of her contributions toward the advancement of scientific research. Dr. Schneeman has also been active in developing state and national nutrition policy as an appointed member of the California State Board of Food and Agriculture and the USD A Public Advisory Board. She is currently president of the Dannon Institute, a nonprofit foundation funded by Dannon, Inc. She has served as chair of the Institute of Medicine (IOM) Committee on Body Composition, Nutrition, and Health of Military Women and recently served as Deputy Administrator for Human Nutrition of the USDA Agricultural Research Service (on leave from U.C. Davis). Dr. Schneeman’s research areas include fat absorption, complex carbohydrates, dietary fiber, and gastrointestinal function.

Daniel L.Azarnoff, M.D. is president of D.L.Azarnoff Associates, through which he does consulting with the pharmaceutical industry. He also serves as Senior Vice President of Clinical/Regulatory Affairs at Cellegy Pharmaceuticals, Inc. The companies he is involved with do not market dietary supplements. Dr. Azarnoff s expertise includes pharmaceutical industry administration, pharmacology, clinical pharmacology, and general internal medicine. His research interests include the drug approval process, including preclinical (pharmacology, toxicology, pharmaceutics) and clinical (therapeutic, bioequivalence trials); drugs to treat hyperlipoproteinemia; and transdermal drug delivery. Dr. Azarnoff earned his M.D. from the University of Kansas where he became KUMC Distinguished Professor of Medicine and Pharmacology and previously served as President of Research and Development for the Searle Pharmaceutical Company. He has been an IOM member since 1978 with membership on



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For Comment: Proposed Framework for Evaluating the Safety of Dietary Supplements Appendix F Biographical Sketches of Committee Members Barbara O.Schneeman, Ph.D. (chair) served formerly as dean, College of Agricultural and Environmental Sciences, and currently serves as a professor of nutrition in the Department of Nutrition and in the Division of Clinical Nutrition and Metabolism, University of California at Davis. Her professional activities include membership on the U.S. Department of Agriculture (USDA)/Department of Health and Human Services 1990 and 1995 Dietary Guidelines for Americans Advisory Committees, the Board of Trustees of the International Life Sciences Institute, and the editorial boards of Proceedings of the Society of Experimental Biology and Medicine, Food and Nutrition Series of Academic Press, Nutrition Reviews, Journal of Nutrition, and California Agriculture. Professional honors include the Institute of Food Technologists’ Samuel Gate Prescott Award for research, the Commissioner’s Special Citation, and the Harvey W.Wiley Medal from the Food and Drug Administration (FDA) in recognition of her contributions toward the advancement of scientific research. Dr. Schneeman has also been active in developing state and national nutrition policy as an appointed member of the California State Board of Food and Agriculture and the USD A Public Advisory Board. She is currently president of the Dannon Institute, a nonprofit foundation funded by Dannon, Inc. She has served as chair of the Institute of Medicine (IOM) Committee on Body Composition, Nutrition, and Health of Military Women and recently served as Deputy Administrator for Human Nutrition of the USDA Agricultural Research Service (on leave from U.C. Davis). Dr. Schneeman’s research areas include fat absorption, complex carbohydrates, dietary fiber, and gastrointestinal function. Daniel L.Azarnoff, M.D. is president of D.L.Azarnoff Associates, through which he does consulting with the pharmaceutical industry. He also serves as Senior Vice President of Clinical/Regulatory Affairs at Cellegy Pharmaceuticals, Inc. The companies he is involved with do not market dietary supplements. Dr. Azarnoff s expertise includes pharmaceutical industry administration, pharmacology, clinical pharmacology, and general internal medicine. His research interests include the drug approval process, including preclinical (pharmacology, toxicology, pharmaceutics) and clinical (therapeutic, bioequivalence trials); drugs to treat hyperlipoproteinemia; and transdermal drug delivery. Dr. Azarnoff earned his M.D. from the University of Kansas where he became KUMC Distinguished Professor of Medicine and Pharmacology and previously served as President of Research and Development for the Searle Pharmaceutical Company. He has been an IOM member since 1978 with membership on

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For Comment: Proposed Framework for Evaluating the Safety of Dietary Supplements numerous IOM committees including the Committee on Halcion, the Committee on Understanding the Biology of Sex and Gender Differences, and the Committee to Assess the System for the Protection of Human Research Subjects. Cindy L.Christiansen, Ph.D. is chief of the Statistics Section, Center for Health Quality, Outcomes, and Economic Research at Bedford Veterans Affairs and an associate professor of health services at Boston University. Dr. Christiansen serves as chair of the American Statistical Association Section on Health Policy Statistics. She is one of the country’s leading experts on hierarchical and predictive models and their use in health services research. Her research interests include the development and implementation of multi-level and prediction models for health service and medical applications, and her methodological work has focused on Poisson models and on models for grouped ordinal data. Alice M.Clark, Ph.D. holds her Ph.D. in pharmacognosy from the University of Mississippi and serves as Vice Chancellor for Research and Sponsored Programs, Frederick A.P.Barnard Distinguished Professor of Pharmacognosy and research professor of the Research Institute of Pharmaceutical Sciences at the University of Mississippi. Prior to assuming her current position in July 2001, Dr. Clark was director of the National Center for Natural Products Research, which operates as a drug discovery and development program that works on acquisition, preparation, and in vitro evaluation of extracts of higher plants for beneficial activity. It combines drug discovery, in vitro, and in vivo evaluations of efficacy and toxicity, working in collaboration with USDA’s Agriculture Research Service and industry to develop therapeutics from plants. Faculty at the Center conduct research on dietary supplements and potential therapeutics. The Center is well known for its efforts in enhancing the safety and efficacy of botanical dietary supplements. Dr. dark’s research interests are in evaluation of natural compounds for antibiotic and antifungal activity, as well as in the utilization of microorganisms as predictive models for drug metabolism and as synthetic adjuncts. She is part of an NCNPR group working on a Centers for Disease Control and Prevention-funded project to evaluate the potential for botanical dietary supplements to interact with pharmaceuticals, to review the scientific literature on specific botanicals, and to review consumer use of botanical dietary supplements. Dr. Clark also serves as associate editor for the Journal of Natural Products. Norman R.Farnsworth, Ph.D. is a distinguished university professor, research professor of pharmacognosy, director of the Pharmacognosy Graduate Program, and the director of the Program for Collaborative Research in the Pharmaceutical Sciences at the University of Illinois at Chicago (UIC). Dr. Farnsworth also serves as director of the UIC/National Institutes of Health (NIH) Dietary Supplements Research Center. He is credited with designing a worldwide computer database called NAPRALERT that compiles scientific literature on the safety and efficacy of herbal medicines, plants, marine organisms, and fungi. As director of the World Health Organization (WHO) Collaborating Center for Traditional Medicine, Dr. Farnsworth has used this database to lead the WHO’S publication of numerous monographs reviewing traditional medicinals. He is a member of Health Canada’s Expert Advisory Committee on Natural Health Products and served on the Commission on Dietary Supplement Labels authorized by the Dietary Supplement Health and Education Act of 1994. Dr. Farnsworth serves on the Scientific Advisory Board of the Herb Research Foundation, the Board of Trustees of the American Botanical Council, and the editorial advisory board of several peer-reviewed journals and Herbalgram. He

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For Comment: Proposed Framework for Evaluating the Safety of Dietary Supplements also consults with various companies on pharmacognosy questions (currently these include Pharmavite, Shaklee, and Tom’s of Maine). He has authored a number of publications about botanicals, including Botanical Dietary Supplements: Quality, Safety, and Efficacy. His research interests include analysis of chemical and biological data on natural products and isolation, identification, and structure elucidation of biologically active plant constituents. Ted Gansler, M.D., M.B.A. is Director of Medical Information Strategy at the American Cancer Society (ACS) and editor of the ACS publication, CA: A Cancer Journal for Clinicians. At ACS, Dr. Gansler is responsible for assuring the accuracy of printed and electronic information products for patients, the general public, and health professionals. He is a graduate of Duke University, University of Pittsburgh School of Medicine, and Georgia State University School of Business Administration, and completed a pathology residency and cytopathology fellowship at the University of Pennsylvania. Dr. Gansler is also an adjunct associate professor of pathology at Emory University. Philip S.Guzelian, M.D. serves as the Director of Medical Toxicology and co-director of the Hepatobiliary Research Center at the University of Colorado Health Sciences Center. Dr. Guzelian earned his M.D. at the University of Wisconsin-Madison. His research interests, largely supported by grants from NIH, include liver disease, hepatic drug metabolism and toxicity, medical toxicology, and cytochrome P450. His research objective is to understand how cells recognize the presence of foreign chemicals and activate host defenses. Dr. Guzelian has been a member of the NIH National Advisory Environmental Health Sciences Council, chairman of the Toxicology Advisory Committee of the Burroughs Wellcome Fund, and a member of the Drug Safety Scientific Advisory Committee for Rhone-Poulenc Rorer Pharmaceuticals, the Board of Scientific Directors of the International Life Sciences Institute, and the Board of Scientific and Policy Advisors of the American Council of Science and Health. He is also an ad hoc member of the Environmental Protection Agency’s (EPA) Office of Science Coordination and Policy Scientific Advisory Panel and has served on EPA’s Science Review Board for the Food Quality Protection Act. Elizabeth Jeffery, Ph.D. serves as a professor of nutritional toxicology for the Department of Food Science and Human Nutrition, the Division of Nutritional Sciences and the Department of Pharmacology at the University of Illinois, Urbana-Champaign. She has a Ph.D. in biochemistry from the University of London (United Kingdom) and teaches and conducts research in the area of safety and efficacy of functional foods and dietary supplements. Dr. Jeffery investigates the potential for soy to affect bone health and for broccoli and other crucifers with major support from NIH and USDA, and a gift from Standard Process, Inc. Dr. Jeffery is past editor of the American Society for Pharmacology and Experimental Therapeutics Drug Metabolism Newsletter and past associate editor of Toxicology and Applied Pharmacology. She is presently chair of the Bioactive Components Research Interest Section of American Society for Nutritional Sciences, chair of the Toxicology Division of American Society for Pharmacology and Experimental Therapeutics, and secretary/treasurer of the Food Safety Specialty Section of the Society of Toxicology. Joseph Lau, M.D. is a professor of medicine at the Tufts University School of Medicine and professor of clinical research at the Sackler School of Graduate Biomedical Sciences at Tufts

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For Comment: Proposed Framework for Evaluating the Safety of Dietary Supplements University. He is also co-director of the New England Cochrane Center and director of one of the twelve Agency for Healthcare Research and Quality Evidence-based Practice Centers located at the New England Medical Center in Boston. Dr. Lau is interested in methodological issues in meta-analysis and the translation of evidence into practice. He developed the method of cumulative meta-analysis and has published extensively on the methodologies and clinical applications of meta-analysis. Dr. Lau is a member of the editorial board of Clinical Evidence and has served on study sections for the Agency for Healthcare Research and Quality Initial Review Group. Dr. Lau received his M.D. from Tufts University School of Medicine. Susan S.Percival, Ph.D. is a professor in the Food Science and Human Nutrition Department at the University of Florida. She is a recipient of the Future Leaders Award from the International Life Sciences Institute Nutrition Foundation. Her research interests include nutrition and immunity; effects of botanicals, phytochemicals, and trace elements on immune function; antioxidant bioavailability and impact on immunity; efficacy of dietary supplements in humans; and mechanistic studies in animal and cell culture models. While much of her research has focused on the metabolism of copper and other trace elements, Dr. Percival’s research currently focuses on health effects of different fruit phytochemicals, echinacea and components of green tea, with support from industry. Cheryl L.Rock, Ph.D., R.D. is a professor in the Department of Family and Preventive Medicine and the Cancer Prevention and Control Program at the University of California, San Diego School of Medicine. She received her Ph.D. in nutritional sciences from the University of California, Los Angeles School of Public Health. Dr. Rock’s primary NTH-funded research efforts are focused on the role of nutritional and dietary factors in the development and progression of cancer in women, particularly breast and cervical cancer, and her research efforts also address eating pathology and weight concerns in women. She is presently involved in randomized trials that are testing whether modifications in diet and level of physical activity can alter biological processes and progression of cancer. She currently serves on editorial boards for several peer-reviewed journals and has been an invited participant in several NIH review committees, workshops, and meetings.