TABLE 2–1 Key Components of Approaches Used by Other Organizations to Evaluate Dietary Supplements

Organization

Purpose of Evaluation

Selection and Types of Substances for Review

Product Endpoints

Agency for Healthcare Research and Quality

Effectiveness

Safety

Variety of types

Reports done at request of other agencies and organizations

Summary report

U.S. Pharmacopeia-National Formulary (USP-NF)

Quality

Variety of types

Selection based on:

Safety

Extent of use

Assessment by pharmacognosists

Ability to meet USP-NF monograph requirements

Evidence of historical use in traditional medicine

Monographs in USP or NF

USP Dietary Supplement Verification Program

Quality

Variety of types

Selection is via manufacturer sponsorship

USP certification mark or no mark

American Herbal Pharmacopoeia

Effectiveness

Quality and analytical methods

Safety

Botanicals commonly used in the United States

Selection based on:

Recommendations of a prioritization committee (professional herbalists, herbal industry, and herbal educators)

Monograph sponsorship (interested organizations or companies)

Selection by other groups

Summary monographs

American Herbal Products Association

Safety

Botanical ingredients sold in North America

Classification as Class 1, 2, 3, or 4

Natural Medicines Comprehensive Database

Effectiveness Safety

Variety of natural medicines sold in the United States and Canada

Summary monographs

Safety assessment classification:

Likely safe

Possibly safe

Possibly unsafe

Likely unsafe

Unsafe

World Health Organization

Effectiveness

Safety

Quality

Botanicals

Selection based on extent of use, worldwide importance, and availability of data

Summary monograph



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement