• it should provide a method to integrate diverse information into a priority-setting scheme so that efforts and resources can be maximally directed toward those dietary supplement ingredients with the greatest safety concerns; and

  • it should provide a mechanism for public input.

Once the definition and key attributes of a safety framework were understood and the committee had an understanding of approaches taken by other expert groups, the committee then developed a framework focused on the safety of dietary supplements. This approach is outlined briefly in the following chapter, with additional detail in succeeding chapters.


AHP (American Herbal Pharmacopoeia). 2002. American Herbal Pharmacopoeia and Therapeutic Compendium: Standards of Analysis, Quality Control, and Therapeutics. Online. Available at http://www.herbal-ahp.org/. Accessed June 19, 2002.

AHRQ (Agency for Healthcare Research and Quality). 2002. Evidence-based Practice Centers. Online. Available at http://www.ahrq.gov/clinic/epc/. Accessed June 17, 2002.

Blumenthal M, ed. 1998. Therapeutic Guide to Herbal Medicines. The Complete German Commission E Monographs. Austin, TX: American Botanical Council.

Chopra A, Doiphode VV. 2002. Ayurvedic medicine. Core concept, therapeutic principles, and current relevance. Med Clin North Am 86:75–89, vii.

CRN (Council for Responsible Nutrition). 1998. Reference on Evaluating Botanicals. Washington, DC: CRN.

Department of Health. 2001. Natural health products regulations. Canada Gazette, Part I 135:4912–4981.

ESCOP (The European Scientific Cooperative on Phytotherapy). 2001. Publications. ESCOP Monographs. Online. Available at http://www.escop.com/publications.htm. Accessed November 12, 2001.

Foster S, Tyler VE. 1999. Tyler‘s Honest Herbal. A Sensible Guide to the Use of Herbs and Related Remedies. 4th ed. New York: Haworth Herbal Press.

Grieve M. 1996. A Modern Herbal. New York: Barnes and Noble.

McGuffin M, Hobbs C, Upton R, Goldberg A. 1997. American Herbal Product Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press.

NMCD (Natural Medicines Comprehensive Database). 2002. About the Database. Online. Available at http://www.naturaldatabase.com/aboutdb.asp. Accessed January 7, 2002.

Select Committee on GRAS Substances. 1982. Insights on Food Safety Evaluation. Rockville, MD: Life Sciences Research Office.

USP (The United States Pharmacopeia). 2001. USP Board of Trustees Agrees to Continue Proceeding with Pilot Program for Dietary Supplement Verification. Online. Available at http://www.usp.org. Accessed October 31, 2001.

USP. 2002a. USP 25-NF 20. Rockville, MD: United States Pharmacopeial Convention, Inc.

USP. 2002b. USP Fact Sheet. Online. Available at http://www.usp.org. Accessed June 18, 2002.

WHO (World Health Organization). 1999. WHO Monographs on Selected Medicinal Plants, Volume I. Geneva: WHO.

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