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Cancer and the Environment: Gene-Enviroment Interaction References Achiwa H, Yatabe Y, Hida T, Kuroishi T, Kozaki K, Nakamura S, Ogawa M, Sugiura T, Mitsudomi T, Takahashi T. 1999. Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. Clinical Cancer Research 5(5):1001–1005. Adams RL, Burdon RH. 1982. DNA methylation in eukaryotes. Critical Reviews in Biochemistry and Molecular Biology 13:349–384. Aguilar F, Hussain SP, Cerutti P. 1993. Aflatoxin B1 induces the transversion of GÆT in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proceedings of the National Academy of Sciences 90(18):8586–8590. Aguilar F, Harris CC, Sun T, Hollstein M, Cemtti, P. 1994. Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264:1317–1319. Ambs S, Merriam WG, Ogunfusika MO, Bennett WP, Ishibe N, Hussain SP, Tzeng EE, Geller DA, Billiar TR, Hanis CC. 1998a. p53 and vascular endothelial growth factor regulate tumour growth of NOS2-expressing human carcinoma cells. Nature Medicine 4:1371–1376. Ambs S, Ogunfusika MO, Merriam WG, Bennett WP, Billiar TR, Harris CC. 1998b. Upregulation of NOS2 expression in cancer-prone p53 knockout mice. Proceedings of the National Academy of Sciences 95:8823–8828. Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Shields PG, Felley-Bosco E, Hussain SP, Ranis CC. 1999. Characteristic p53 mutations correlate with inducible NO synthase expression in human colorectal cancer. Journal of the National Cancer Institute 91:86–88. Ames BN, Shigenaga MK, Gold LS. 1993. DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis. Environmental Health Perspectives 101(5):35–44. Armitage P, Doll R. 1954. The age distribution of cancer and a multi-stage theory of carcinogenesis. British Journal of Cancer 8:1–12. Barclay BJ, Kunz BA, Little JG, Haynes RH. 1982. Genetic and biochemical consequences of thymidylate stress. Canadian Journal of Biochemistry 60:172–184. Baron JA, Sandler RS, Haile RW, Mandel JS, Mott LA, Greenberg ER. 1998. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. Journal of the National Cancer Institute 90:57–62. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Rejthar A, Kovarik J, Lane DP. 1990. Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. International Journal of Cancer 46(5):839–844. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. 1998. Alterations in DNA methylation: A fundamental aspect of neoplasia. Advances in Cancer Research 72:141–196.

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