Bloland, Peter B., Williams, Holly A.. "Appendix B: Methodology for Efficacy Assessment of In Vivo Malaria Therapy." Malaria Control During Mass Population Movements and Natural Disasters. Washington, DC: The National Academies Press, 2002.
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Malaria Control During Mass Population Movements and Natural Disasters
RIII: a Day 2 parasite density that is greater than (>25) percent of the day 0 parasite density.
RII: a positive Day 2 blood smear with a parasite density that is less than or equal to (=) 25 percent of the Day 0 density and a positive Day 7 blood smear.
Early RI:EITHER
Negative Day 2 blood smear with a positive blood smear on any day between Day 3 and Day 14, OR
Positive Day 2 blood smear with a parasite density that is less than (<) 25 percent of Day 0,
Negative Day 7 blood smear,
Positive blood smear on any day between Day 8 and Day 14.
Sensitive/Late RI
A Day 2 parasite density that is less than (<) 25 percent of the Day 0 density AND negative blood smears on every follow-up examination between Day 7 and Day 14.
With follow-up periods of 14 days, it is not possible to distinguish sensitive responses from late recrudescences, and these responses are combined in the RI/S category. For follow-up periods longer than 14 days, the “late RI” definition is applied to any reappearance of parasites between Day 14 and the end of follow-up. “Sensitive” responses are reserved for those patients not experiencing reappearance of parasites for the duration of follow-up.
