1. RIII: a Day 2 parasite density that is greater than (>25) percent of the day 0 parasite density.

  2. RII: a positive Day 2 blood smear with a parasite density that is less than or equal to (=) 25 percent of the Day 0 density and a positive Day 7 blood smear.

  3. Early RI: EITHER

    • Negative Day 2 blood smear with a positive blood smear on any day between Day 3 and Day 14, OR

    • Positive Day 2 blood smear with a parasite density that is less than (<) 25 percent of Day 0,

    • Negative Day 7 blood smear,

    • Positive blood smear on any day between Day 8 and Day 14.

  1. Sensitive/Late RI

    • A Day 2 parasite density that is less than (<) 25 percent of the Day 0 density AND negative blood smears on every follow-up examination between Day 7 and Day 14.

With follow-up periods of 14 days, it is not possible to distinguish sensitive responses from late recrudescences, and these responses are combined in the RI/S category. For follow-up periods longer than 14 days, the “late RI” definition is applied to any reappearance of parasites between Day 14 and the end of follow-up. “Sensitive” responses are reserved for those patients not experiencing reappearance of parasites for the duration of follow-up.



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