TABLE 3-3 Antimalarial Drugs for Uncomplicated Malaria

 

Dosing (all per os)a

 

Drug Name

Use

Adult

Pediatric

Contra-indications

Cost (US$)b

Comments

Combination Therapy

MQ + artesunate

Treatment of nonsevere falciparum infections thought to be CQ and SP-resistant.

15 mg/kg MQ base on day 2 of treatment, followed by 10 mg/kg MQ base on day 3. Usual adult dose is 750 mg on day 2 followed by 500 mg on day 3.

15 mg/kg MQ on day 2 of treatment followed by 10 mg/kg MQ on day 3.

See under MQ monotherapy.

3.90

Safety of artemisinins and MQ during first trimester of pregnancy not established. Vomiting after MQ can be reduced by administering it on the second and third days after an initial dose of artesunate.

Artemisinin (20 mg/kg initially followed by 10 mg / kg once daily for 2 more days) can be substituted can besubstituted for artesunate.

 

4 mg/kg artesunate daily for 3 days.

4 mg/kg artesunate daily for 3 days.

 



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