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Workshop Agenda

CHALLENGES FOR THE CHEMICAL SCIENCES IN THE 21 ST CENTURY

WORKSHOP ON NATIONAL SECURITY AND HOMELAND DEFENSE

Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering 100 Academy, Irvine, CA

Monday-Wednesday, January 14-16, 2002

AGENDA

Monday, January 14, 2002

7:30

BREAKFAST

SESSION I. CONTEXT AND OVERVIEW

8:00

Introductory remarks by organizers.

Background of project.

8:00

DOUGLAS J. RABER, National Research Council

8:05

RONALD BRESLOW AND MATTHEW V. TIRRELL, Co-Chairs, Committee on Challenges for the Chemical Sciences in the 21st Century

8:20

JOHN I. BRAUMAN, Co-Chair, Organizing Committee for the Workshop on National Security and Homeland Defense



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Page 51 C Workshop Agenda CHALLENGES FOR THE CHEMICAL SCIENCES IN THE 21 ST CENTURY WORKSHOP ON NATIONAL SECURITY AND HOMELAND DEFENSE Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering 100 Academy, Irvine, CA Monday-Wednesday, January 14-16, 2002 AGENDA Monday, January 14, 2002 7:30 BREAKFAST SESSION I. CONTEXT AND OVERVIEW 8:00 Introductory remarks by organizers. Background of project. 8:00 DOUGLAS J. RABER, National Research Council 8:05 RONALD BRESLOW AND MATTHEW V. TIRRELL, Co-Chairs, Committee on Challenges for the Chemical Sciences in the 21st Century 8:20 JOHN I. BRAUMAN, Co-Chair, Organizing Committee for the Workshop on National Security and Homeland Defense

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Page 52 8:30 DAVID R. FRANZ, Southern Research Institute Current Thought on Bioterrorism: The Threat, Preparedness, and Response 9:05 DISCUSSION 9:25 SCOTT D. CUNNINGHAM, DuPont What Can the Industrial Chemical Community Contribute to the Nation's Security? 10:00 DISCUSSION 10:20 BREAK 10:50 RICHARD L. GARWIN, IBM and Council on Foreign Relations, New York Thoughts and Questions on Countering the Terrorist Threat 11:25 DISCUSSION 11:45 LUNCH SESSION II. ANTICIPATION, DETECTION, AND RESPONSE 1:00 ROLF I. DEININGER, The University of Michigan Vulnerability of Public Water Supplies 1:30 DISCUSSION 1:50 ANDREA W. CHOW, Caliper Technologies Corp. Microfluidics: Development, Applications, and Future Challenges 2:20 DISCUSSION 2:40 BREAKOUT SESSION: DISCOVERY What advances or breakthroughs in the chemical sciences—related to national security and homeland defense—have been made in the past several decades? 3:45 BREAK 4:00 Reports from breakout sessions and discussion 5:00 RECEPTION 6:00 BANQUET Speaker—RALPH J. CICERONE, University of California, Irvine After September 11: An Expanded Agenda for Science and Scientists Tuesday, January 15, 2002 7:30 BREAKFAST SESSION III. REAL-TIME DETECTION 8:00 DONALD H. STEDMAN, University of Denver A Skeptical Analysis of Chemical and Biological Weapons Detection Schemes 8:30 DISCUSSION 8:50 KIMBERLY A. PRATHER, University of California, San Diego Overview of Real-Time Single Particle Mass Spectrometry Methods

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Page 53 9:20 DISCUSSION 9:40 BREAKOUT SESSION: CHALLENGES What are the grand challenges in the chemical sciences for which solutions would assist the nation's interests in national security and homeland defense? 10:45 BREAK 11:00 Reports from breakout sessions and discussion 12:00 LUNCH SESSION IV. CLEANUP AND VERIFICATION 1:00 MARK D. TUCKER, Sandia National Laboratories New Approaches to Decontamination at DOE 1:30 DISCUSSION 1:50 STEPHEN R. QUAKE, California Institute of Technology How Integration Will Make Microfluidics Useful 2:20 DISCUSSION 2:40 BREAKOUT SESSION: TECHNICAL BARRIERS What are the technical impediments to solving the grand challenges? 3:45 BREAK 4:00 Reports from breakout sessions and discussion 5:00 ADJOURN FOR DAY Wednesday, January 16, 2002 7:30 BREAKFAST SESSION V. PRE-RESPONSE ACTIVITIES 8:00 C. RICHARD HUTCHINSON, Kosan Biosciences Biosynthetic Engineering of Polyketide Natural Products 8:30 DISCUSSION 8:50 MAURICIO FUTRAN, Bristol-Myers Squibb Challenges in Rapid Scale-up of Synthetic Pharmaceutical Processes 9:00 DISCUSSION 9:40 BREAKOUT SESSION: RESEARCH NEEDS What areas of fundamental research must be pursued to overcome the barriers? 10:45 BREAK 11:00 Reports from breakout sessions and discussion 12:00 Wrap-up and closing remarks JOHN L. ANDERSON, Co-Chair, Organizing Committee for the Workshop on National Security and Homeland Defense 12:15 ADJOURN

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Page 54 EXECUTIVE SESSION OF ORGANIZING COMMITTEE 12:15 Working lunch: General discussion 1:00 Develop consensus findings 1:45 Develop consensus recommendations 2:30 Develop action items, follow-up steps, and assignments 3:30 ADJOURN