TABLE 6-1 Immunosuppressive Effects of JP-8 Exposure in Humans and Experimental Animals

Species or Cell Line

Exposure Concentration

Exposure Duration

Effects

Reference

INHALATION EXPOSURE

Human

Measurements taken in breathing zones of subjects; median concentration of naphthalene, 1.9 μg/m3 (low-exposure group), 447 μg/m3 (high-exposure group); median concentration of benzene, 3.1 μg/m3 (low-exposure group), 242 μg/m3 (high-exposure group)

High-exposure group, persistent exposure to JP-8(defined as at least 1 hr twice per wk for at least 9 mo); low-exposure group, no significant exposure to jet fuel or solvents

High-exposure group had higher white-cell counts than low-exposure group; there were increased numbers of neutrophils and monocytes but no differences in total lymphocytes, T cells, NK cells, B cells; white cell, neutrophil, and monocyte counts in high-exposure group did not exceed range of normal values

Rhodes et al. 2001a

Human

Exposed group (5,706 people) had potential occupational exposure to JP-8. Control group (5,706 people) did not work in occupations in which exposure to JP-8 would occur

Not reported

Health-event analysis did not find differences in immunologic measures (such as infections) between exposed and control groups

Gibson et al. 2001aa

Human

Measurements taken in breathing zones of subjects; median concentration of naphthalene, 1.9 μg/m3 (low-exposure group), 10.4 μg/m3 (moderate-exposure group),

High- and moderate-exposure groups, persistent exposure to JP-8; low exposure group, no significant

Analysis of self-assessment questionnaire did not report differences among groups in immunologic-related illnesses

Gibson et al. 2001ba



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