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Advancing Prion Science: Guidance for the National Prion Research Program -- Interim Report (2003)
Medical Follow-Up Agency (MFUA)
 Institute of Medicine (IOM)

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. "2. Prion Diseases and Their Challenges." Advancing Prion Science: Guidance for the National Prion Research Program -- Interim Report. Washington, DC: The National Academies Press, 2003.

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TABLE 2-1 Classification of TSEs

Type of TSE

Affected Mammals

Modes of Natural Transmission

Date First Recognized

In humans

Sporadic Creutzfeldt-Jakob disease (sCJD)

 

Unknown

1920

Sporadic fatal insomnia (sFI)

Unknown

1999

Familial Creutzfeldt-Jakob disease

Genetic

1924a

Fatal familial insomnia (FFI)

Genetic

1986b

Gerstmann-Straussler-Scheinker disease

Genetic

1936c

Kuru

Exposure to contaminated human tissues during endocannibalistic rituals

1957

latrogenic Creutzfeldt-Jakob disease

CJD-infected surgical equipment or tissue transplants

1974d

Variant Creutzfeldt-Jakob disease (vCJD)

Eating BSE-infected tissue; other modese

1996
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