References

REPORTS, PUBLISHED AND PRESENTED PAPERS, AND MATERIAL AVAILABLE ONLINE

Amgen. 2001. Amgen and NASA Team Up to Tap Weightless Environment of Space as Lab to Test Osteoporosis Treatment. News release. Available online at <http://www.amgentrials.com/news/releases/NewsRelease_20011127>. Accessed April 25, 2003.

Apseloff, G., Girten, B., Walker, M., Shepard, D.R., Krecic, M.E., Stern, L.S., and Gerber, N. 1993. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats. J. Pharmacol. Exp. Ther. 264: 1071-1078.

Ashby, N. 2002. Relativity and the Global Positioning System. Phys. Today 55(5): 41.


Badhwar, B.D. 2002. Shuttle radiation dose measurements in the International Space Station orbits. Radiat. Res. 157: 69-75.

Badhwar, B.D., Atwell, W., Badavi, F.F., Yang, T.C., and Cleghorn, T.F. 2002. Space radiation absorbed dose distribution in a human phantom. Radiat. Res. 157: 76-91.

Bateman, T.A., Dunstan, C.R., Ferguson, V.L., Lacey, D.L., Ayers, R.A., and Simske, S.J. 2000. Osteoprotegerin mitigates tail suspension-induced osteopenia. Bone 26: 443-449.

Bateman, T.A., Dunstan, C.R., Ferguson, V.L., Lacey, D.L., Ayers, R.A., and Simske, S.J. 2001. Osteoprotegerin ameliorates sciatic nerve crush induced bone loss. J. Orthop. Res. 19: 518-523.

Berg, R.F., Moldover, M.R., and Zimmerli, G.A. 1999. Phys. Rev. Lett. 82: 920.


Canadian Space Agency. 2001. Minister of Industry John Manley and American Astronaut John Glenn Share Successful Results of Osteoporosis Experiment. Press release. Available online at <http://www.spaceref.com/news/viewpr.html?pid=1765>. Accessed April 25, 2003.


ESA (European Space Agency), Directorate of Manned Spaceflight and Microgravity. 1999. Bone Analysis Module (BAM). Available online at <http://www.estec.esa.int/spaceflight/epm/epmbam.htm>. Accessed April 25, 2003.

ESA. 2001. European Modular Cultivation System. Available online at <http://www.spaceflight.esa.int/users/file.cfm?filename=fac-iss-dest-emcs>. Accessed April 25, 2003.

ESA. 2002. Biolab. Available online at <http://www.spaceflight.esa.int/users/biolab>. Accessed April 25, 2003.


Friedman, R., and Ross, H.D. 2001. Combustion technology and fire safety for human-crew space missions. Microgravity Combustion Fire in Free Fall (H.D. Ross, ed.). Academic Press, San Diego, Calif.


Grigoriev, A.I., Morukov, B.V., Oganov, V.S., Rakhmanov, A.S., and Buravkova, L.B. 1992. Effect of exercise and bisphosphonate on mineral balance and bone density during 360 day antiorthostatic hypokinesia. J. Bone Miner. Res. 7: S449-S455.

Guignandon, A., Genty, C., Vico, L., Lafage-Proust, M.H., Palle, S., and Alexandre, C. 1997. Demonstration of feasibility of automated osteoblastic line culture in space flight. Bone 20: 109-116.

Guignandon, A., Lafage-Proust, M.H., Usson, Y., Laroche, N., Caillot-Augusseau, A., Alexandre, C., and Vico, L. 2001. Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions. FASEB J. 15: 2036-2038.


Institute of Medicine (IOM). 2001. Safe Passage: Astronaut Care for Exploration Missions. National Academy Press, Washington, D.C.

International Space Station Management and Cost Evaluation (IMCE) Task Force. 2001. International Space Station (ISS) Management and Cost Evaluation (IMCE) Report to the NASA Advisory Council. Available online at <ftp://ftp.hq.nasa.gov/pub/pao/reports/2001/imce.pdf>.


Keller, T.S., Strauss, A.M., and Szpalski, M. 1992. Prevention of bone loss and muscle atrophy during manned space flight. Microgravity Q. 2: 89-102.



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Factors Affecting the Utilization of the International Space Station for Research in the Biological and Physical Sciences References REPORTS, PUBLISHED AND PRESENTED PAPERS, AND MATERIAL AVAILABLE ONLINE Amgen. 2001. Amgen and NASA Team Up to Tap Weightless Environment of Space as Lab to Test Osteoporosis Treatment. News release. Available online at <http://www.amgentrials.com/news/releases/NewsRelease_20011127>. Accessed April 25, 2003. Apseloff, G., Girten, B., Walker, M., Shepard, D.R., Krecic, M.E., Stern, L.S., and Gerber, N. 1993. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats. J. Pharmacol. Exp. Ther. 264: 1071-1078. Ashby, N. 2002. Relativity and the Global Positioning System. Phys. Today 55(5): 41. Badhwar, B.D. 2002. Shuttle radiation dose measurements in the International Space Station orbits. Radiat. Res. 157: 69-75. Badhwar, B.D., Atwell, W., Badavi, F.F., Yang, T.C., and Cleghorn, T.F. 2002. Space radiation absorbed dose distribution in a human phantom. Radiat. Res. 157: 76-91. Bateman, T.A., Dunstan, C.R., Ferguson, V.L., Lacey, D.L., Ayers, R.A., and Simske, S.J. 2000. Osteoprotegerin mitigates tail suspension-induced osteopenia. Bone 26: 443-449. Bateman, T.A., Dunstan, C.R., Ferguson, V.L., Lacey, D.L., Ayers, R.A., and Simske, S.J. 2001. Osteoprotegerin ameliorates sciatic nerve crush induced bone loss. J. Orthop. Res. 19: 518-523. Berg, R.F., Moldover, M.R., and Zimmerli, G.A. 1999. Phys. Rev. Lett. 82: 920. Canadian Space Agency. 2001. Minister of Industry John Manley and American Astronaut John Glenn Share Successful Results of Osteoporosis Experiment. Press release. Available online at <http://www.spaceref.com/news/viewpr.html?pid=1765>. Accessed April 25, 2003. ESA (European Space Agency), Directorate of Manned Spaceflight and Microgravity. 1999. Bone Analysis Module (BAM). Available online at <http://www.estec.esa.int/spaceflight/epm/epmbam.htm>. Accessed April 25, 2003. ESA. 2001. European Modular Cultivation System. Available online at <http://www.spaceflight.esa.int/users/file.cfm?filename=fac-iss-dest-emcs>. Accessed April 25, 2003. ESA. 2002. Biolab. Available online at <http://www.spaceflight.esa.int/users/biolab>. Accessed April 25, 2003. Friedman, R., and Ross, H.D. 2001. Combustion technology and fire safety for human-crew space missions. Microgravity Combustion Fire in Free Fall (H.D. Ross, ed.). Academic Press, San Diego, Calif. Grigoriev, A.I., Morukov, B.V., Oganov, V.S., Rakhmanov, A.S., and Buravkova, L.B. 1992. Effect of exercise and bisphosphonate on mineral balance and bone density during 360 day antiorthostatic hypokinesia. J. Bone Miner. Res. 7: S449-S455. Guignandon, A., Genty, C., Vico, L., Lafage-Proust, M.H., Palle, S., and Alexandre, C. 1997. Demonstration of feasibility of automated osteoblastic line culture in space flight. Bone 20: 109-116. Guignandon, A., Lafage-Proust, M.H., Usson, Y., Laroche, N., Caillot-Augusseau, A., Alexandre, C., and Vico, L. 2001. Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions. FASEB J. 15: 2036-2038. Institute of Medicine (IOM). 2001. Safe Passage: Astronaut Care for Exploration Missions. National Academy Press, Washington, D.C. International Space Station Management and Cost Evaluation (IMCE) Task Force. 2001. International Space Station (ISS) Management and Cost Evaluation (IMCE) Report to the NASA Advisory Council. Available online at <ftp://ftp.hq.nasa.gov/pub/pao/reports/2001/imce.pdf>. Keller, T.S., Strauss, A.M., and Szpalski, M. 1992. Prevention of bone loss and muscle atrophy during manned space flight. Microgravity Q. 2: 89-102.

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Factors Affecting the Utilization of the International Space Station for Research in the Biological and Physical Sciences Kreitenberg, A., Baldwin, K.M., Bagian, J.P., Cotton, S., Witmer, J., and Caiozzo, V.J. 1998. The “space cycle” self powered human centrifuge: A proposed countermeasure for prolonged human spaceflight. Aviat. Space Environ. Med. 69: 66-72. LeBlanc, A., Shackelford, L., and Schneider, V. 1998. Future human bone research in space. Bone 22: 113S-116S. Miyamoto, A., Shigematsu, T., Fukunaga, T., Kawakami, K., Mukai, C., and Sekiguchi, C. 1998. Medical baseline data collection on bone and muscle change with space flight. Bone 5S: 79S-82S. Musgrave, M.E., Kuang, A., Xiao, Y., Stout, S.C., Bingham, G.E., Briarty, L.C., Levinskikh, M.A., Sychev, V.N., and Podolski, I.G. 2000. Gravity independence of seed-to-seed cycling in Brassica rapa. Planta 210: 400-406. NASA (National Aeronautics and Space Administration). 1998a. The International Space Station Research Plan: An Overview. NASA, Washington, D.C. NASA. 1998. Astronaut Medical Evaluation Requirements Document (AMERD), JSC 24834. NASA Johnson Space Center, Houston, Tex. NASA. 2001a. Human Research Facility Rack 1. Fact Sheet FS-2001-02-43-MSFC. Available online at <http://www.msfc.nasa.gov/NEWSROOM/background/facts/hrf.html>. Accessed April 25, 2003. NASA. 2001b. NASA Success Story. The Biomass Production System (BPS). Available online at: <http://technology.ksc.nasa.gov/WWWaccess/Stories/BiomassSS.pdf>. Accessed April 25, 2003. NASA. 2001c. Ongoing ResearchTask Book. NASA/OBPR Research Opportunities. Available online at <http://peer1.nasaprs.com/peer_review/taskbook/taskbook.html>. Accessed April 25, 2003. NASA. 2002a. Fluids and Combustion Facility Overview. Available online at <http://fcf.grc.nasa.gov./pages/overview.html>. Accessed March 4, 2002. NASA. 2002b. International Space Station Payload Operations Concept and Architecture Assessment Study Final Report (Executive Summary). Available online at <http://www.spaceref.com/news/viewsr.html?pid=4713>. Accessed April 25, 2003. NASA. 2002c. NASA Human Space Flight. Available online at <http://spaceflight.nasa.gov/station>. Accessed April 25, 2003. NASA, Office of Biological and Physical Research (OBPR). 2001. Human Physiology Research and the ISS: Staying Fit Along the Journey. Available online at <http://spaceresearch.nasa.gov/general_info/issphysiology.html>. Accessed April 25, 2003. NASA, Office of Biological and Physical Research (OBPR). 2002. Research on Station. NASA Space Research 2002. Available online at <http://spaceresearch.nasa.gov/research_projects/ros/ros.html >. Accessed April 25, 2003. NASA, Public Affairs. 2002. Expedition Five Press Kit. NASA/United Space Alliance, NASA Johnson Space Center, Houston, Tex. Available online at <http://www.shuttlepresskit.com>. Accessed April 25, 2003. NRC (National Research Council), Board on Radiation Effects Research. 1990. Health Effects of Exposure to Low Levels of Ionizing Radiation (BEIR V). National Academy Press, Washington, D.C. NRC, Space Studies Board. 1995. Microgravity Research Opportunities for the 1990s. National Academy Press, Washington, D.C. NRC, Space Studies Board. 1998. A Strategy for Research in Space Biology and Medicine in the New Century. National Academy Press, Washington, D.C. NRC, Space Studies Board. 2000a. Future Biotechnology Research on the International Space Station. National Academy Press, Washington, D.C. NRC, Space Studies Board. 2000b. Review of NASA’s Biomedical Research Program. National Academy Press, Washington, D.C. NRC, Space Studies Board. 2001. Readiness Issues Related to Research in the Biological and Physical Sciences on the International Space Station. National Academy Press, Washington, D.C. NewsRX.com. 2001. Osteoporosis: NASA experiments on bone loss may benefit Earth patients first. Immunotherapy Weekly, December 19.

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Factors Affecting the Utilization of the International Space Station for Research in the Biological and Physical Sciences O’Malley, T.F., and Weiland, K.J. 2001. The FCF Combustion Integrated Rack: Microgravity Combustion Science On Board the International Space Station. AIAA-2001-4927. Paper presented at the AIAA Conference and Exhibit on the International Space Station, October 15-18, 2001. Ohshima, H., Sekiguchi, C., Mizumo, K., Shigematsuand, T., and Watanabe, Y. 2002. Bone loss countermeasure program for Japanese astronauts. Aviat. Space Environ. Med. 73(3): 250. Ross, Howard D., ed. 2001. Microgravity Combustion Fire in Free Fall. Academic Press, San Diego, Calif. Sacksteder, K.R., and T’ien, J.S. 1994. Buoyant downward diffusion flame spread and extinction in partial gravity acceleration. Twenty-Fifth Symposium (International) on Combustion. Combustion Institute, Pittsburgh, Pa. Schneider, V., Oganov, V., LeBlanc, A., Rakmonov, A., Taggart, L., Bakulin, A., Huntoon, C., Grigoriev, A., and Varonin, L. 1995. Bone and body mass changes during space flight. Acta Astron. 36: 463-466. Swiger, R.R. 2001. Just how does the cII selection system work in MutaTM mouse? Environ. Mol. Mutagenesis 37(4): 290-296. Todd, P., Pecaut, M.J., and Fleshner, M. 1999. Combined effects of space flight factors and radiation on humans. Mut. Res. 430: 211-219. Turner, R.T. 2000. Physiology of a microgravity environment: Invited review: What do we know about the effects of spaceflight on bone? J. Appl. Physiol. 89: 840-847. University of Wisconsin-Madison, College of Engineering. 2001. WCSAR Reaps First Crop of Seeds from International Space Station. Available online at <http://www.engr.wisc.edu/news/headlines/2001/Aug20.html>. Vasques, M., Lang, C., Grindeland, R.E., Roy, R.R., Daunton, N., Bigbee, A.J., and Wade, C.E. 1998. Comparison of hyper- and microgravity on rat muscle, organ weights and selected plasma constituents. Aviat. Space Environ. Med. 69: A2-A8. Vico, L., Collet, P., Guiganandon, A., Lafage-Proust, M.H., Thomas, T., Rehaillia, M., and Alexandre, C. 2000. Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355: 1607-1611. Wade, C.E., Harper, J.S., Daunton, N.G., Corcoran, M.L., and Morey-Holton, E. 1997. Body mass change during altered gravity: Spaceflight, centrifugation, and return to 1 G. J. Gravit. Physiol. 4: 43-48. Wisconsin Center for Space Automation and Robotics (WSCAR). 2001. Advanced Astroculture (ADVASC). Available online at <http://wcsar.engr.wisc.edu/advasc.html>. LETTERS, PRESENTATIONS, AND OTHER MATERIAL Bellan, Josette, Jet Propulsion Laboratory, letter to Kathie L. Olsen, dated April 30, 2001. Edelman, Raymond, Boeing Company (retired), e-mail to Representative Boehlert, dated April 3, 2001. Egolfopoulos, Fokion, University of Southern California, letter to Daniel Goldin, dated April 16, 2001. Fettman, M.J., College of Veterinary Medicine and Biomedical Sciences, Colorado State University, letter to Joel Rothenberg on funding for the Space Biological Research Project, dated March 9, 2001. Fogelman, G., presentation to the Task Group on Research on the International Space Station, April 2, 2001. Gregory, F., Office of Space Flight Status, NASA, presentation to the NASA Advisory Council, June 11, 2002. International Space Life Sciences Working Group (ISLSWG), Space Life Sciences and Space Sciences Flight Experiments Information Package 2001, NASA, Washington, D.C., 2001. Katovich, M.J., University of Florida, College of Pharmacy, letter to the Honorable Barbara A. Mikulski on funding for the Space Station Biological Research Project, dated June 28, 2001. Law, Chung K., Princeton University, Department of Mechanical and Aerospace Engineering, letter to Daniel S. Goldin, dated September 7, 1999.

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Factors Affecting the Utilization of the International Space Station for Research in the Biological and Physical Sciences Law, Chung K., Princeton University, Department of Mechanical and Aerospace Engineering, letter to Daniel S. Goldin, dated March 14, 2001. Liskowsky, D.R., NASA, ReMaP Task Force White Paper, Fundamental Space Biology, April 18, 2002[a]. Liskowsky, D.R., NASA, presentation to the Task Group on Research on the International Space Station, Washington, D.C., March 5, 2002[b]. Olsen, K., NASA, presentation to the Task Group on Research on the International Space Station, November 27, 2001. Ostrach, L.H., presentation to the Task Group on Research on the International Space Station, April 12, 2002. Pearlman, Howard, University of Southern California, letter to Daniel Goldin, dated April 11, 2001. Robey, J., Physical Sciences Research Program—ISS Restructure, NASA, presentation to the Task Group on Research on the International Space Station, October 2001. Robey, J., List of ISS racks and modules, e-mail distribution, May 27, 2002. Schowengerdt, Franklin D., Center for Commercial Application of Combustion in Space, letter to Daniel Goldin, dated April 13, 2001. Sekerka, R.F., Carnegie Mellon University Department of Physics, letter to the Honorable Barbara A. Mikulski on behalf of materials science discipline working group, dated June 27, 2001[a]. Sekerka, R.F., Carnegie Mellon University Department of Physics, letter to the Honorable Barbara A. Mikulski on the level of ISS research funding, dated August 23, 2001[b]. Sekerka, R.F. Carnegie Mellon University Department of Physics, presentation to the Committee on Microgravity Research, October 2001[c]. Sekerka, R.F., Carnegie Mellon University Department of Physics, letter to the Honorable Sean O’Keefe on the ISS/materials science research program, dated February 8, 2002. Syed, Saadat, Pratt and Whitney, letter to Joseph Rothenberg, dated May 4, 2001. T’ien, James S., National Center for Microgravity Research on Fluids and Combustion, letter to Joseph Rothenberg, dated April 3, 2001. Trinh, E., NASA, Fundamental Research Enabled by the Microgravity Environment, presentation to the Task Group on Research on the International Space Station, April 2, 2001. Trinh, E., NASA, response to follow-up questions from the Task Group on Research on the International Space Station, dated March 15, 2002[a]. Trinh, E., NASA,ISS Physical Sciences Research, Cellular Biotechnology, presentation to the Task Group on Research on the International Space Station, April 12, 2002[b]. Uri, J.J., ISS Research Status: The First Year of Operations, presentation to Space Station Advisory Subcommittee, February 12, 2002. U.S. Sections, Combustion Institute. 2001. Letter to D.S. Goldin, dated March 29, 2001. Available online at <http://users.lmi.net/jokeller/wss/US_J_EC/Nasa_let.htm>. Accessed May 30, 2002. Voorhees, P.W., Committee on Microgravity Research, presentation to REMAP Task Force, April 2002. Wargo, M., telephone communications, April 10 and June 29, 2002.