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(Sackler NAS Colloquium) Self-Perpetuating Structural States in Biology, Disease, and Genetics (2002)
Proceedings of the National Academy of Sciences (PNAS)

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. "Chaperoning brain degeneration." (Sackler NAS Colloquium) Self-Perpetuating Structural States in Biology, Disease, and Genetics. Washington, DC: The National Academies Press, 2002.

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Front Matter (R1-R6)
Self-perpetuating structural states in biology, disease, and genetics (1-1)
Transmission of prions (2-7)
Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein (8-15)
Interactions among prions and prion “strains” in yeast (16-23)
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington (24-30)
Chaperoning brain degeneration (31-35)
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity (36-42)
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases (43-50)
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity (51-56)
The insulation of genes from external enhancers and silencing chromatin (57-61)
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast (62-69)
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+] (70-77)
Heritable chromatin structure: Mapping “memory” in histones H3 and H4 (78-85)
Does heterochromatin protein 1 always follow code? (86-93)
Self-perpetuating epigenetic pili switches in bacteria (94-100)
Histone H3 variants specify modes of chromatin assembly (101-108)
Induction and maintenance of nonsymmetrical DNA methylation in Neurospora (109-114)
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes (115-122)
RNA-directed DNA methylation in Arabidopsis (123-134)